The RodentGPOmics Atlas: a comprehensive database of rodent biology for genomes and pathogens

IF 16.6 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zhiwen Jiang, Ziqing Yan, Yali Hou, Jia Tang, Mengdi Zheng, Meng Lu, Xiang Ji, Karthik Gangavarapu, Xinxin Li, Shuo Su
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引用次数: 0

Abstract

Rodents represent the most abundant order of mammals, exhibiting remarkable diversity in morphology, habitats, behaviors, and hosted pathogens. Significant attention is currently focused on rodents as experimental animals for biomedical research. However, numerous aspects of rodents remain unexplored, such as their potential in unconventional biomedical models, molecular underpinnings of intriguing complex phenotypes, adaptations to environment or climate change, and host-pathogen interactions and arms race evolution. These challenges require a systematic framework to integrate the genomic variations among rodents with information on rodent-borne pathogens. To address this gap, we have established a comprehensive, freely accessible, and user-friendly atlas named Rodent Genome and Pathogen multi-Omics (RodentGPOmics), which provides comparative analysis of rodent genomes and information on zoonotic pathogen sequences in rodents. The RodentGPOmics Atlas provides: (i) basic information on 2706 rodent species; (ii) chromosome-level visualization of genomes, functional annotations, and genomic comparisons across 121 rodent species; (iii) epidemiological profiles based on 21 852 pathogen sequences reported in rodents and (iv) a few genomic tools for in-depth exploration of rodent multi-omics. This resource aims to advance the development of biomedical models for humans for promoting public health, as well as innovate the genetics, genomics, and molecular evolution in rodents, and offer valuable knowledge on rodent-borne emerging/re-emerging zoonotic infectious diseases. The resources are freely available and easy-to-use at http://RodentGPOmics.njau.edu.cn:8888/Rodent/index/homePage.
啮齿类基因组学图谱:一个全面的啮齿类生物基因组和病原体数据库
啮齿动物是哺乳动物中数量最多的一目,在形态、栖息地、行为和寄主病原体等方面表现出显著的多样性。啮齿类动物作为生物医学研究的实验动物,目前备受关注。然而,啮齿动物的许多方面仍未被探索,例如它们在非常规生物医学模型中的潜力,有趣的复杂表型的分子基础,对环境或气候变化的适应,宿主-病原体相互作用和军备竞赛进化。这些挑战需要一个系统的框架来整合啮齿动物之间的基因组变异和啮齿动物传播的病原体的信息。为了解决这一问题,我们建立了一个全面的、免费访问的、用户友好的地图集,名为啮齿动物基因组和病原体多组学(RodentGPOmics),它提供了啮齿动物基因组的比较分析和啮齿动物人畜共患病原体序列的信息。啮齿类动物图谱提供:(i) 2706种啮齿类动物的基本资料;(ii)染色体水平的基因组可视化、功能注释和121种啮齿动物的基因组比较;(iii)基于啮齿类动物报告的21 852个病原体序列的流行病学概况;(iv)深入探索啮齿动物多组学的一些基因组工具。该资源旨在促进人类生物医学模型的发展,以促进公共卫生,以及创新啮齿动物的遗传学,基因组学和分子进化,并提供有关啮齿动物传播的新发/再发人畜共患传染病的宝贵知识。这些资源可以在http://RodentGPOmics.njau.edu.cn:8888/Rodent/index/homePage上免费获得并易于使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nucleic Acids Research
Nucleic Acids Research 生物-生化与分子生物学
CiteScore
27.10
自引率
4.70%
发文量
1057
审稿时长
2 months
期刊介绍: Nucleic Acids Research (NAR) is a scientific journal that publishes research on various aspects of nucleic acids and proteins involved in nucleic acid metabolism and interactions. It covers areas such as chemistry and synthetic biology, computational biology, gene regulation, chromatin and epigenetics, genome integrity, repair and replication, genomics, molecular biology, nucleic acid enzymes, RNA, and structural biology. The journal also includes a Survey and Summary section for brief reviews. Additionally, each year, the first issue is dedicated to biological databases, and an issue in July focuses on web-based software resources for the biological community. Nucleic Acids Research is indexed by several services including Abstracts on Hygiene and Communicable Diseases, Animal Breeding Abstracts, Agricultural Engineering Abstracts, Agbiotech News and Information, BIOSIS Previews, CAB Abstracts, and EMBASE.
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