HHV-6B, HHV-7, and B19V Are Frequently Found DNA Viruses in the Human Thymus but Show No Definitive Link with Myasthenia Gravis

The Journal of Infectious Diseases Pub Date : 2024-12-10 DOI:10.1093/infdis/jiae600

Kirsten Nowlan, Leo Hannolainen, Irini M Assimakopoulou, Pia Dürnsteiner, Joona Sarkkinen, Santeri Suokas, Lea Hedman, Pentti J Tienari, Klaus Hedman, Mikael Niku, Leena-Maija Aaltonen, Antti Huuskonen, Jari V Räsänen, Ilkka K Ilonen, Mikko I Mäyränpää, Johannes Dunkel, Sini M Laakso, Maria Söderlund-Venermo, Maria F Perdomo, Eliisa Kekäläinen

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Abstract

Myasthenia gravis (MG) is a rare autoimmune disorder characterised by muscle weakness resulting from autoantibody-mediated disruption of the neuromuscular junction. Notably, it is also frequently associated with thymic pathology. This study explores the relationship between MG and DNA viruses in the thymus, employing targeted NGS and qPCR to analyse thymic tissue samples from both MG patients and healthy controls. We detected HHV-6B, HHV-7, EBV, and B19V across various tissue groups. However, no significant enrichment of these viruses was observed in the thymic tissue of MG patients. Additionally, we confirmed a dormant persistence of B19V within the thymus of seropositive individuals. These findings indicate that DNA viruses are unlikely to serve as primary environmental triggers for MG.

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HHV-6B、HHV-7和B19V是人类胸腺中常见的DNA病毒，但与重症肌无力没有明确的联系

重症肌无力（MG）是一种罕见的自身免疫性疾病，其特征是由自身抗体介导的神经肌肉连接破坏引起的肌肉无力。值得注意的是，它也经常与胸腺病理有关。本研究探讨了MG与胸腺DNA病毒之间的关系，采用靶向NGS和qPCR分析了MG患者和健康对照组的胸腺组织样本。我们在不同的组织组中检测到HHV-6B、HHV-7、EBV和B19V。然而，在MG患者的胸腺组织中没有观察到这些病毒的显著富集。此外，我们证实了血清阳性个体胸腺内B19V的休眠持久性。这些发现表明，DNA病毒不太可能是MG的主要环境触发因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Journal of Infectious Diseases

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