Dehydrogenative Photoredox Catalyzed Synthesis of Indolyl Δ2‐Isoxazolines via a Formal C(sp3)−H Functionalization

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-03-24 DOI:10.1002/ejoc.202401369

Jonathan Da Luz , Farhaan Dobah , James A. Rossi‐Ashton , Richard J. Payne , William P. Unsworth , Wade F. Petersen

引用次数: 0

Abstract

The discovery of a dehydrogenative photoredox catalyzed formal C(sp³)−H intramolecular cyclization of indolyl‐oximes to generate indolyl Δ²‐isoxazolines is reported. In contrast to the current state‐of‐the‐art, the reaction avoids the use of super stoichiometric chemical oxidants and high reaction temperatures and is proposed to operate via two sequential single electron oxidation events.

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脱氢光氧化还原催化合成吲哚酰Δ2 -异恶唑啉的正式C(sp3) -H功能化。

报道了一种脱氢光氧化还原催化吲哚酰肟分子内正构C(sp3) - H环化生成吲哚酰Δ2 -异恶唑啉的方法。与目前的技术相比，该反应避免了使用超化学计量化学氧化剂和高反应温度，并建议通过两个连续的单电子氧化事件进行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.