Recent Advances in Photoredox/Chromium Dual‐Catalyzed Carbonyl Addition Reactions: A Review

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-02-04 DOI:10.1002/adsc.202401315

Bin Xiao , Kangping Wu , Mianling Zhang , Haixiang Hu , Xiaochong Guo

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Abstract

The chromium‐catalysed Nozaki‐Hiyama‐Kishi (NHK) reaction is a very dependable technique for alcohol synthesis and is extensively used in the complete synthesis of natural compounds. The majority of these reactions occur via a reductive‐radical‐polar crossover (RRPCO) mechanism, which is crucial for the transformation of reactive radical intermediates. The production of radicals using photoinduced catalytic reactions is now among the most effective approaches. The photoinduced chromium‐catalysed addition reaction to carbonyl compounds is an effective technique for alcohol synthesis that integrates the benefits of photocatalysis with chromium catalysis. Photocatalysis significantly enhances the diversity of radical production, hence broadening the substrate scope in the chromium‐catalysed NHK reaction. This paper primarily examines the photoredox chromium dual‐catalysed carbonyl addition process for alcohol synthesis, including numerous methods for radical generation.

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光氧化还原/铬双催化羰基加成反应的研究进展

铬催化Nozaki - Hiyama - Kishi （NHK）反应是一种非常可靠的醇合成技术，广泛用于天然化合物的完全合成。这些反应大多通过还原-自由基-极性交叉（RRPCO）机制发生，这对于活性自由基中间体的转化至关重要。利用光诱导催化反应产生自由基是目前最有效的方法之一。光诱导铬催化羰基化合物加成反应是一种有效的醇合成技术，它综合了光催化和铬催化的优点。光催化显著增强了自由基生成的多样性，从而拓宽了铬催化NHK反应的底物范围。本文主要研究了光氧化还原铬双催化羰基加成工艺用于酒精合成，包括多种自由基生成方法。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.