Recent Advances in Photoredox/Chromium dual‐Catalyzed Carbonyl Addition Reactions: A Review

Abstract

The chromium‐catalysed Nozaki‐Hiyama‐Kishi (NHK) reaction is a very dependable technique for alcohol synthesis and is extensively used in the complete synthesis of natural compounds. The majority of these reactions occur via a reductive‐radical‐polar crossover (RRPCO) mechanism, which is crucial for the transformation of reactive radical intermediates. The production of radicals using photoinduced catalytic reactions is now among the most effective approaches. The photoinduced chromium‐catalysed addition reaction to carbonyl compounds is an effective technique for alcohol synthesis that integrates the benefits of photocatalysis with chromium catalysis. Photocatalysis significantly enhances the diversity of radical production, hence broadening the substrate scope in the chromium‐catalysed NHK reaction. This paper primarily examines the photoredox chromium dual‐catalysed carbonyl addition process for alcohol synthesis, including numerous methods for radical generation.