Morphogenesis and regeneration share a conserved core transition cell state program that controls lung epithelial cell fate

IF 10.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2024-12-11 DOI:10.1016/j.devcel.2024.11.017

Xiangyi Ke, Benjamin van Soldt, Lukas Vlahos, Yizhuo Zhou, Jun Qian, Joel George, Claudia Capdevila, Ian Glass, Kelley Yan, Andrea Califano, Wellington V. Cardoso

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Abstract

Transitional cell states are at the crossroads of crucial developmental and regenerative events, yet little is known about how these states emerge and influence outcomes. The alveolar and airway epithelia arise from distal lung multipotent progenitors, which undergo cell fate transitions to form these distinct compartments. The identification and impact of cell states in the developing lung are poorly understood. Here, we identified a population of Icam1/Nkx2-1 epithelial progenitors harboring a transitional state program remarkably conserved in humans and mice during lung morphogenesis and regeneration. Lineage-tracing and functional analyses reveal their role as progenitors to both airways and alveolar cells and the requirement of this transitional program to make distal lung progenitors competent to undergo airway cell fate specification. The identification of a common progenitor cell state in vastly distinct processes suggests a unified program reiteratively regulating outcomes in development and regeneration.

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形态发生和再生共享一个保守的核心转化细胞状态程序，控制肺上皮细胞的命运

过渡性细胞状态处于关键发育和再生事件的十字路口，但对这些状态如何出现和影响结果知之甚少。肺泡上皮和气道上皮起源于远端肺多能祖细胞，它们经历细胞命运转变形成这些不同的隔室。在发育中的肺细胞状态的鉴定和影响是知之甚少。在这里，我们发现了一群Icam1/Nkx2-1上皮祖细胞，它们在人类和小鼠的肺形态发生和再生过程中具有显著保守的过渡状态程序。谱系追踪和功能分析揭示了它们作为气道和肺泡细胞的祖细胞的作用，以及这种过渡程序使远端肺祖细胞能够接受气道细胞命运规范的要求。在截然不同的过程中发现了一个共同的祖细胞状态，这表明在发育和再生过程中有一个统一的程序反复调节结果。

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.