Influence of Genetic Ancestry on Gene-Environment Interactions of Polygenic Risk and Sociocultural Factors: Results from the Hispanic Community Health Study/Study of Latinos.

Jayati Sharma, Cristin E McArdle, Mariaelisa Graff, Christina Cordero, Martha Daviglus, Linda C Gallo, Carmen R Isasi, Tanika N Kelly, Krista M Perreira, Gregory A Talavera, Jianwen Cai, Kari E North, Lindsay Fernández-Rhodes, Genevieve L Wojcik
{"title":"Influence of Genetic Ancestry on Gene-Environment Interactions of Polygenic Risk and Sociocultural Factors: Results from the Hispanic Community Health Study/Study of Latinos.","authors":"Jayati Sharma, Cristin E McArdle, Mariaelisa Graff, Christina Cordero, Martha Daviglus, Linda C Gallo, Carmen R Isasi, Tanika N Kelly, Krista M Perreira, Gregory A Talavera, Jianwen Cai, Kari E North, Lindsay Fernández-Rhodes, Genevieve L Wojcik","doi":"10.1101/2024.11.26.24318009","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Many present analyses of Hispanic/Latino populations in epidemiologic research aggregate all members of this ethnic group, despite immense diversity in genetic backgrounds, environment, and culture between and across Hispanic/Latino background groups. Using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we examined the role of self-identified background group and genetic ancestry proportions in gene-environment interactions influencing the relationship between body mass index (BMI) and a polygenic score for BMI (PGS<sub>BMI</sub>).</p><p><strong>Methods: </strong>Weighted univariate and multivariable generalized linear models were executed to compare the effects of environmental variables identified <i>a priori</i> by McArdle et al. 2021. Both Amerindigenous (AME) ancestry proportion and background group identity were statistically modeled as confounders both through stratified and joint analyses to understand their influence on the relationship between BMI and PGS<sub>BMI</sub>, while incorporating gene-environment interactions of PGS x diet and PGS x age-at-immigration.</p><p><strong>Results: </strong>After complex survey weighting, 7,075 participants remained in the analytic sample, representing individuals of six background groups: Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American. The distributions of key environmental and sociocultural variables were heterogeneous between Hispanic/Latino background groups. Associations of these variables with AME ancestry were similarly heterogeneous upon stratification, indicating confounding by background group. In a predictive model for BMI incorporating health, immigration, and environmental variables, PGS<sub>BMI</sub> performance decreased with increasing AME ancestry proportion. In this model, most statistically significant GxE interactions lost significance after ancestry and background stratification, except for PGS x age-at-immigration interactions in some strata: Mexican background individuals born in the US compared to those >=21 years old at migration (β=1.33, p<0.01), Dominican background individuals 6-12 years old at migration compared to those >=21 years old at migration (β=4.38, p<0.001), and Cuban background individuals 0-5 years old at migration compared to those >=21 years old at migration (β=2.20, p=0.015), where US-born includes individuals born in the US 50 states/DC.</p><p><strong>Conclusions: </strong>Controlling for self-identified background group identity and genetic ancestry did not eliminate statistically significant differences in interactions between AME ancestry and environmental variables in certain strata of AME ancestry among some Hispanic/Latino background groups in HCHS/SOL.</p>","PeriodicalId":94281,"journal":{"name":"medRxiv : the preprint server for health sciences","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623730/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv : the preprint server for health sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.11.26.24318009","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Many present analyses of Hispanic/Latino populations in epidemiologic research aggregate all members of this ethnic group, despite immense diversity in genetic backgrounds, environment, and culture between and across Hispanic/Latino background groups. Using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we examined the role of self-identified background group and genetic ancestry proportions in gene-environment interactions influencing the relationship between body mass index (BMI) and a polygenic score for BMI (PGSBMI).

Methods: Weighted univariate and multivariable generalized linear models were executed to compare the effects of environmental variables identified a priori by McArdle et al. 2021. Both Amerindigenous (AME) ancestry proportion and background group identity were statistically modeled as confounders both through stratified and joint analyses to understand their influence on the relationship between BMI and PGSBMI, while incorporating gene-environment interactions of PGS x diet and PGS x age-at-immigration.

Results: After complex survey weighting, 7,075 participants remained in the analytic sample, representing individuals of six background groups: Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American. The distributions of key environmental and sociocultural variables were heterogeneous between Hispanic/Latino background groups. Associations of these variables with AME ancestry were similarly heterogeneous upon stratification, indicating confounding by background group. In a predictive model for BMI incorporating health, immigration, and environmental variables, PGSBMI performance decreased with increasing AME ancestry proportion. In this model, most statistically significant GxE interactions lost significance after ancestry and background stratification, except for PGS x age-at-immigration interactions in some strata: Mexican background individuals born in the US compared to those >=21 years old at migration (β=1.33, p<0.01), Dominican background individuals 6-12 years old at migration compared to those >=21 years old at migration (β=4.38, p<0.001), and Cuban background individuals 0-5 years old at migration compared to those >=21 years old at migration (β=2.20, p=0.015), where US-born includes individuals born in the US 50 states/DC.

Conclusions: Controlling for self-identified background group identity and genetic ancestry did not eliminate statistically significant differences in interactions between AME ancestry and environmental variables in certain strata of AME ancestry among some Hispanic/Latino background groups in HCHS/SOL.

遗传祖先对多基因风险和社会文化因素的基因-环境相互作用的影响:来自西班牙裔社区健康研究/拉丁裔研究的结果
背景:目前流行病学研究中对西班牙裔/拉丁裔人群的许多分析汇总了该种族的所有成员,尽管西班牙裔/拉丁裔背景群体之间和之间的遗传背景、环境和文化存在巨大差异。利用西班牙裔社区健康研究/拉丁裔研究(HCHS/SOL),我们研究了自我认定的背景群体和遗传祖先比例在影响体重指数(BMI)和BMI多基因评分(PGS BMI)之间关系的基因-环境相互作用中的作用。方法:采用加权单变量和多变量广义线性模型来比较McArdle等人2021年先验确定的环境变量的影响。通过分层和联合分析,将美洲原住民(AME)血统比例和背景群体身份作为混杂因素进行统计建模,以了解它们对体重指数和PGS体重指数之间关系的影响,同时纳入PGS x饮食和PGS x移民年龄的基因-环境相互作用。结果:经过复杂的调查加权,7075名参与者留在分析样本中,代表六个背景群体的个人:中美洲,古巴,多米尼加,墨西哥,波多黎各和南美洲。关键环境和社会文化变量的分布在西班牙裔/拉丁裔背景群体之间存在异质性。这些变量与AME血统的关联在分层上同样是异质的,表明背景组存在混淆。在纳入健康、移民和环境变量的BMI预测模型中,PGS的BMI表现随着AME血统比例的增加而下降。在该模型中,大多数统计上显著的GxE相互作用在血统和背景分层后失去了显著性,除了某些阶层的PGS与移民年龄的相互作用:墨西哥背景的美国出生的个体与>=21岁移民的个体相比(β=1.33, p=21岁移民(β=4.38, p=21岁移民(β=2.20, p=0.015),其中US-born包括出生在美国50个州/DC的个体。结论:在HCHS/SOL的一些西班牙裔/拉丁裔背景人群中,控制自我认同的背景群体身份和遗传祖先并不能消除AME祖先与某些AME祖先阶层的环境变量之间相互作用的统计学显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信