Dietary inflammatory index scores and cognitive aging: results from the Framingham heart Study offspring cohort.

Debora Melo van Lent, Paul F Jacques, Sokratis M Charisis, Hannah Gokingco Mesa, Claudia Satizabal, Changzheng Yuan, Ramachandran S Vasan, Sudha Seshadri, Alexa Beiser, Jayandra J Himali, Mini E Jacob
{"title":"Dietary inflammatory index scores and cognitive aging: results from the Framingham heart Study offspring cohort.","authors":"Debora Melo van Lent, Paul F Jacques, Sokratis M Charisis, Hannah Gokingco Mesa, Claudia Satizabal, Changzheng Yuan, Ramachandran S Vasan, Sudha Seshadri, Alexa Beiser, Jayandra J Himali, Mini E Jacob","doi":"10.1101/2024.11.27.24318084","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Nutritional factors can abet or protect against systemic chronic inflammation, which plays an important role in the development and progression of dementia. We evaluated whether higher (i.e. pro-inflammatory) Dietary Inflammatory Index (DII) scores were associated with cognitive decline in the community-based Offspring Framingham Heart Study (FHS).</p><p><strong>Method: </strong>1,614 older adults (mean age 61 years [standard deviation (SD)], 9;55% women]) completed validated 126-item Food Frequency Questionnaires (FFQ), administered at FHS examination cycle 7 (1998-2001) and examination cycle 5 (1991-1995) and/or 6 (1995-1998). We created a DII score (based on the published method by Shivappa et al. 2014) for each available exam; a cumulative DII score was calculated by averaging exam-specific scores across the two or three exams. Cognitive testing was completed at call back sessions following examination cycles 7 and 8 (2005-2008). Exam 7 was considered as study baseline and participants were followed over a mean time of seven years (SD 1). We excluded participants with prevalent dementia at baseline and those with no cognitive testing data at either/or exams 7 and 8. We examined associations between the cumulative DII score and cognitive test scores over time using annualized change adjusting for age, sex, education (model 1) and additionally for exam 7 measures of body mass index, total energy intake, total cholesterol: high-density lipoprotein ratio, smoking and anti-cholesterol medication (model 2).</p><p><strong>Results: </strong>Higher DII scores were significantly associated with (less) decline in performance on Similarities (verbal comprehension/reasoning) and Global cognition, following adjustments for model 1 covariates (Model 1:β and SE, 0.017, 0.008,p=0.03; 0.004,0.002,p=0.02, respectively). The effect sizes remained similar after additional adjustment for Model 2 covariates (0.018, 0.009,p=0.06; 0.004, 0.002,p=0.03, respectively). Additionally, we found that higher DII scores associated with accelerated decline in performance on Trail Making B-A (processing speed and executive function) (Model 2: -0.010, 0.004,p=0.03). We observed no relationships between higher DII scores and other neuropsychological tests. Further, stratified analyses revealed a linear relationship between higher DII scores and (less) decline in performance on Hooper visual organization among men, but not women (Model 2: 0.022, 0.010,p=0.02; -0.011, 0.009,p=0.23, respectively).</p><p><strong>Conclusion: </strong>Higher DII scores were associated with (less) cognitive decline. We take our unexpected findings with caution as we previous have seen a relationship between higher DII scores and increased risk for dementia. To date, such studies have been very limited, most studies that found a relationship were cross-sectional and have used less sensitive testing. Future longitudinal studies with sensitive neuropsychological test measures are encouraged to elucidate whether a longitudinal relationship between higher DII scores and age-related cognitive decline exists.</p>","PeriodicalId":94281,"journal":{"name":"medRxiv : the preprint server for health sciences","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623757/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv : the preprint server for health sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.11.27.24318084","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Nutritional factors can abet or protect against systemic chronic inflammation, which plays an important role in the development and progression of dementia. We evaluated whether higher (i.e. pro-inflammatory) Dietary Inflammatory Index (DII) scores were associated with cognitive decline in the community-based Offspring Framingham Heart Study (FHS).

Method: 1,614 older adults (mean age 61 years [standard deviation (SD)], 9;55% women]) completed validated 126-item Food Frequency Questionnaires (FFQ), administered at FHS examination cycle 7 (1998-2001) and examination cycle 5 (1991-1995) and/or 6 (1995-1998). We created a DII score (based on the published method by Shivappa et al. 2014) for each available exam; a cumulative DII score was calculated by averaging exam-specific scores across the two or three exams. Cognitive testing was completed at call back sessions following examination cycles 7 and 8 (2005-2008). Exam 7 was considered as study baseline and participants were followed over a mean time of seven years (SD 1). We excluded participants with prevalent dementia at baseline and those with no cognitive testing data at either/or exams 7 and 8. We examined associations between the cumulative DII score and cognitive test scores over time using annualized change adjusting for age, sex, education (model 1) and additionally for exam 7 measures of body mass index, total energy intake, total cholesterol: high-density lipoprotein ratio, smoking and anti-cholesterol medication (model 2).

Results: Higher DII scores were significantly associated with (less) decline in performance on Similarities (verbal comprehension/reasoning) and Global cognition, following adjustments for model 1 covariates (Model 1:β and SE, 0.017, 0.008,p=0.03; 0.004,0.002,p=0.02, respectively). The effect sizes remained similar after additional adjustment for Model 2 covariates (0.018, 0.009,p=0.06; 0.004, 0.002,p=0.03, respectively). Additionally, we found that higher DII scores associated with accelerated decline in performance on Trail Making B-A (processing speed and executive function) (Model 2: -0.010, 0.004,p=0.03). We observed no relationships between higher DII scores and other neuropsychological tests. Further, stratified analyses revealed a linear relationship between higher DII scores and (less) decline in performance on Hooper visual organization among men, but not women (Model 2: 0.022, 0.010,p=0.02; -0.011, 0.009,p=0.23, respectively).

Conclusion: Higher DII scores were associated with (less) cognitive decline. We take our unexpected findings with caution as we previous have seen a relationship between higher DII scores and increased risk for dementia. To date, such studies have been very limited, most studies that found a relationship were cross-sectional and have used less sensitive testing. Future longitudinal studies with sensitive neuropsychological test measures are encouraged to elucidate whether a longitudinal relationship between higher DII scores and age-related cognitive decline exists.

饮食炎症指数评分和认知衰老:来自弗雷明汉心脏研究后代队列的结果。
背景:营养因子可以促进或预防全身性慢性炎症,这在痴呆的发生和发展中起着重要作用。在基于社区的后代弗雷明汉心脏研究(FHS)中,我们评估了较高(即促炎)饮食炎症指数(DII)评分是否与认知能力下降有关。方法:1614名老年人(平均年龄61岁[标准差(SD), 9;55%为女性])完成了经验证的126项食物频率问卷(FFQ),在FHS检查周期7(1998-2001)、检查周期5(1991-1995)和/或6(1995-1998)进行。我们为每个可用的考试创建了DII评分(基于Shivappa等人2014年发表的方法);累积DII分数是通过平均两到三次考试的特定考试分数来计算的。认知测试在检查周期7和8(2005-2008)后的回访会议中完成。测试7被视为研究基线,参与者平均随访时间为7年(SD 1)。我们排除了基线时患有普遍痴呆的参与者以及在测试7和8中没有认知测试数据的参与者。我们使用调整年龄、性别、教育程度的年化变化(模型1),以及身体质量指数、总能量摄入、总胆固醇:高密度脂蛋白比、吸烟和抗胆固醇药物(模型2),检验了累积DII评分与认知测试分数之间随时间的关系。根据模型1协变量(模型1:β和SE, 0.017, 0.008,p=0.03)的调整,较高的DII分数与相似性(言语理解/推理)和整体认知的表现下降(较少)显著相关;分别为0.004,0.002,p = 0.02)。在对模型2协变量进行额外调整后,效应量仍然相似(0.018,0.009,p=0.06;0.004, 0.002,p=0.03)。此外,我们发现较高的DII分数与Trail Making B-A(处理速度和执行功能)的性能加速下降有关(模型2:-0.010,0.004,p=0.03)。我们观察到较高的DII分数与其他神经心理测试之间没有关系。此外,分层分析显示,在男性中,较高的DII分数与Hooper视觉组织表现(较少)下降之间存在线性关系,但在女性中没有(模型2:0.022,0.010,p=0.02;-0.011, 0.009,p=0.23)。结论:较高的DII评分与认知能力下降(较少)相关。我们对这些意外的发现持谨慎态度,因为我们之前已经看到了较高的DII分数与痴呆风险增加之间的关系。迄今为止,这类研究非常有限,大多数发现这种关系的研究都是横断面的,并且使用了不太敏感的测试。未来的纵向研究鼓励采用敏感的神经心理学测试措施来阐明高DII评分与年龄相关的认知能力下降之间是否存在纵向关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信