[Advances in pathogenic mechanisms and pulmonary rehabilitation strategies for skeletal muscle dysfunction in chronic obstructive pulmonary disease].

L L Wu, W He, F J Lin, Y F Xie, Y F Du, W J Lu
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引用次数: 0

Abstract

Chronic obstructive pulmonary disease (COPD) is a complex heterogeneous chronic respiratory disease and third leading cause of death worldwide. In addition to damage to the respiratory system, COPD has significant extra-pulmonary effects, of which skeletal muscle dysfunction is one of the most prominent. Skeletal muscle dysfunction in COPD can manifest as impaired muscle strength, loss of muscle mass, or decreased endurance, etc. Possible pathogenic mechanisms include abnormal neuro-muscular stimulation, dysregulated protein synthesis, hypoxia, inflammation, oxidative stress, mitochondrial dysfunction, impaired regenerative capacity, etc. Pulmonary rehabilitation (PR) can improve limb muscle function, exercise tolerance and quality of life of COPD patients. Exercise training is usually the main component of any PR program. Currently, PR is the main intervention for skeletal muscle dysfunction in COPD and could be executed in PR center, at home, or in the community using state-of-the-art technology. In this review, we summarized recent advances in pathogenic mechanisms and pulmonary rehabilitation strategies for skeletal muscle dysfunction in COPD, in particular exercise training protocols, respiratory support and feedback in PR, and so on.

慢性阻塞性肺疾病骨骼肌功能障碍的发病机制及肺康复策略研究进展
慢性阻塞性肺疾病(COPD)是一种复杂的异质性慢性呼吸系统疾病,是全球第三大死亡原因。除了对呼吸系统的损害外,COPD还具有显著的肺外影响,其中骨骼肌功能障碍是最突出的影响之一。慢性阻塞性肺病骨骼肌功能障碍可表现为肌肉力量受损、肌肉质量损失或耐力下降等。可能的发病机制包括神经肌肉刺激异常、蛋白质合成失调、缺氧、炎症、氧化应激、线粒体功能障碍、再生能力受损等。肺康复(PR)可以改善COPD患者的肢体肌肉功能、运动耐量和生活质量。运动训练通常是任何公关计划的主要组成部分。目前,PR是COPD骨骼肌功能障碍的主要干预措施,可以在PR中心、家庭或社区使用最先进的技术进行。本文综述了近年来COPD骨骼肌功能障碍的发病机制和肺康复策略,特别是运动训练方案、呼吸支持和反馈等方面的研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
3.50
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