Amplitude-integrated electroencephalography showed alterations in cerebral activity in monochorionic twins with twin-to-twin transfusion syndrome.

IF 2.4 4区 医学 Q1 PEDIATRICS
Acta Paediatrica Pub Date : 2024-12-09 DOI:10.1111/apa.17532
Christina Schreiner, Anna Staudt, Vera Neubauer, Ursula Kiechl-Kohlendorfer, Elke Griesmaier
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引用次数: 0

Abstract

Aim: Monochorionic twins are at higher risk of perinatal mortality and morbidity, primarily due to pregnancy-related complications, such as twin-to-twin transfusion syndrome (TTTS). We aimed to investigate whether amplitude-integrated electroencephalography (aEEG) signals are different between monochorionic twins with and without TTTS.

Methods: This was a retrospective single-centre study conducted at Innsbruck Medical University Hospital, Austria. Preterm infants born before 32 weeks of gestation between 6 November 2010 and 6 December 2022 were eligible. The aEEG was analysed for the total maturation score, its component scores and the number of sleep-wake cycles per hour.

Results: We enrolled 79 monochorionic twin infants (48% male) and 157 dichorionic (62% male) twin infants. We found no differences between these two groups of preterm infants regarding the total maturation and component scores, or the number of sleep wake cycles. Monochorionic twins with TTTS showed significantly lower total maturation scores and individual component scores compared to monochorionic twins without TTTS.

Conclusion: Preterm infants with TTTS showed differences in neonatal aEEG signals. Whether these differences are caused by prematurity-related or TTTS-related factors, such as hemodynamic and metabolic changes due to placental anastomoses, should be investigated in future prospective studies, to gain more insight into this important topic.

波幅整合脑电图显示单绒毛膜双胞胎双胎输血综合征的大脑活动改变。
目的:单绒毛膜双胞胎围产期死亡率和发病率的风险较高,主要是由于妊娠相关并发症,如双胎输血综合征(TTTS)。我们的目的是研究有和没有TTTS的单绒毛膜双胞胎的振幅积分脑电图(aEEG)信号是否不同。方法:这是一项在奥地利因斯布鲁克医科大学医院进行的回顾性单中心研究。2010年11月6日至2022年12月6日期间妊娠32周前出生的早产儿符合条件。分析aEEG的总成熟度评分,其组成评分和每小时睡眠-觉醒周期数。结果:我们招募了79名单绒毛膜双胞胎婴儿(48%男性)和157名双绒毛膜双胞胎婴儿(62%男性)。我们发现这两组早产儿在总成熟度和成分评分或睡眠觉醒周期数量方面没有差异。与没有TTTS的单绒毛膜双胞胎相比,TTTS的单绒毛膜双胞胎的总成熟度评分和个体成分评分显着降低。结论:TTTS早产儿在新生儿aEEG信号上存在差异。这些差异是由早产相关因素还是ttts相关因素引起的,如胎盘吻合术引起的血流动力学和代谢变化,需要在未来的前瞻性研究中进行研究,以更深入地了解这一重要课题。
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来源期刊
Acta Paediatrica
Acta Paediatrica 医学-小儿科
CiteScore
6.50
自引率
5.30%
发文量
384
审稿时长
2-4 weeks
期刊介绍: Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries
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