Cost-effectiveness of the adjuvanted RSVPreF3 vaccine among adults aged ≥60 years in the United States.

IF 4.1 4区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Human Vaccines & Immunotherapeutics Pub Date : 2024-12-31 Epub Date: 2024-12-09 DOI:10.1080/21645515.2024.2432745
Elizabeth M La, Jonathan Graham, David Singer, Daniel Molnar, Sara Poston, Desmond Curran, Jessica Pickett, Frederik Verelst
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Abstract

Respiratory syncytial virus (RSV) is a common cause of acute respiratory illness in individuals of all ages, with adults aged ≥60 years and adults with certain chronic conditions at increased risk of severe RSV-related outcomes. This study evaluates the cost-effectiveness of the adjuvanted RSVPreF3 vaccine versus no vaccine in adults aged ≥60 years in the United States (US). A multi-cohort Markov model was developed with a 5-year time horizon and 1-month cycle length to compare outcomes for no vaccination and one-time adjuvanted RSVPreF3 vaccination (assuming the same vaccination as for influenza vaccines). Clinical parameters (e.g., vaccine efficacy) were based on phase 3 clinical trial data over 3 seasons, with all other inputs obtained from public US sources and scientific literature. Outcomes included total and incremental quality-adjusted life year (QALY) losses and costs, as well as incremental cost-effectiveness ratios (ICERs). Sensitivity analyses were conducted to evaluate the sensitivity of results to inputs. In the base case, the model estimated that vaccinating 52.7 million adults aged ≥60 years with the adjuvanted RSVPreF3 vaccine once would result in 244,424 fewer QALY losses and an incremental societal cost of $4.5 billion over 5 years, with vaccination costs partially offset by reduced disease-related costs. From the societal perspective, adjuvanted RSVPreF3 vaccination resulted in an ICER of $18,430 per QALY gained. Results were relatively robust across sensitivity analyses and indicate that adjuvanted RSVPreF3 vaccination is a cost-effective option for the prevention of RSV in US adults aged ≥ 60 years, reducing the substantial burden within this population.

佐剂RSVPreF3疫苗在美国≥60岁成人中的成本效益
呼吸道合胞病毒(RSV)是所有年龄段个体急性呼吸道疾病的常见病因,年龄≥60岁的成年人和患有某些慢性疾病的成年人发生严重RSV相关结局的风险增加。本研究评估了美国≥60岁成人接种RSVPreF3佐剂疫苗与不接种疫苗的成本-效果。建立了一个多队列马尔可夫模型,时间跨度为5年,周期长度为1个月,以比较未接种疫苗和一次性接种RSVPreF3佐剂疫苗的结果(假设接种疫苗与流感疫苗相同)。临床参数(如疫苗效力)基于3个季节的3期临床试验数据,所有其他输入均来自美国公共来源和科学文献。结果包括总和增量质量调整生命年(QALY)损失和成本,以及增量成本-效果比(ICERs)。进行敏感性分析以评价结果对输入的敏感性。在基本情况下,该模型估计,为5270万名年龄≥60岁的成年人接种一次RSVPreF3佐剂疫苗,将使QALY损失减少244,424人,5年内增加的社会成本为45亿美元,疫苗接种成本部分被减少的疾病相关成本所抵消。从社会角度来看,rsvpre3佐剂疫苗接种导致每增加一个QALY的ICER为18,430美元。敏感性分析的结果相对稳健,表明佐剂RSVPreF3疫苗接种是预防60岁以上美国成年人RSV的一种经济有效的选择,减轻了该人群的负担。
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来源期刊
Human Vaccines & Immunotherapeutics
Human Vaccines & Immunotherapeutics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-IMMUNOLOGY
CiteScore
7.90
自引率
8.30%
发文量
489
审稿时长
3-6 weeks
期刊介绍: (formerly Human Vaccines; issn 1554-8619) Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics. Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.
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