=Retinal ischemic perivascular lesions are associated with increased carotid artery stenotic degree.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-12-03 DOI:10.1097/IAE.0000000000004354

Hang Wang, Le Cao, William Robert Kwapong, Ruishan Liu, Yuyin Yan, Jincheng Wan, Guina Liu, Fayun Hu, Bo Wu

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引用次数: 0

Abstract

Purpose: Retinal ischemic perivascular lesions (RIPLs) have been reported as potential biomarkers for cardiovascular diseases and stroke. We aimed to investigate the RIPLs in carotid artery stenosis (CAS) patients and their association with stenotic degree.

Methods: Patients with unilateral CAS or carotid artery occlusion were recruited. Optical coherence tomography (OCT) was conducted for assessing the presence, number, and distribution of RIPLs. OCT angiography (OCTA) was used for evaluating microvascular density in superficial vascular complex (SVC) and deep vascular complex (DVC).

Results: Eighty hundred and fifty-four eyes from 474 CAS patients were included. Ipsilateral eyes had more PRILs compared to contralateral eyes (all p < 0.01). CAS patients with cerebral infarction had a higher incidence and broader distribution of RIPLs compared to those without infarction (both p <0.05). The presence, number, and distribution of RIPLs were positively associated with stenotic degree (all p < 0.001). Eyes with RIPLs had lower SVC density (p = 0.020) compared to eyes without RIPLs.

Conclusions: RIPLs are anatomical markers of ischemia and are suggested to be associated with cerebral infarction and stenotic degree in CAS patients. OCT/OCTA is a noninvasive tool to detect retinal ischemic changes and quantitatively measure retinal microvascular changes in CAS patients.

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视网膜缺血性血管周围病变与颈动脉狭窄程度增加有关。

目的：视网膜缺血性血管周围病变（RIPLs）已被报道为心血管疾病和脑卒中的潜在生物标志物。我们的目的是探讨颈动脉狭窄（CAS）患者的RIPLs及其与狭窄程度的关系。方法：选取单侧CAS或颈动脉闭塞患者。光学相干层析成像（OCT）用于评估ripl的存在、数量和分布。应用OCT血管造影（OCTA）评价浅血管复合体（SVC）和深血管复合体（DVC）微血管密度。结果：纳入474例CAS患者的854只眼。同侧眼PRILs高于对侧眼（p < 0.01）。结论：脑梗死患者的ripl是脑缺血的解剖学标记物，与脑梗死和脑狭窄程度有关。OCT/OCTA是一种检测视网膜缺血性改变和定量测量视网膜微血管变化的无创工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.