{"title":"A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022.","authors":"Cai-Xia Yang, Xiu-Yun Jiang, Xiao-Hong Li","doi":"10.1515/med-2024-1058","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Prader-Willi Syndrome (PWS) is a rare disorder that was initially documented by Prader and Willi in 1956. Despite significant advancements in the understanding of PWS over recent decades, no bibliometric studies have been reported on this field. We aimed to analyze and explore the research trends and hotspots of PWS using a bibliometric analysis to understand the future development of basic and clinical research.</p><p><strong>Methods: </strong>The literature regarding PWS was retrieved from the Web of Science Core Collection Science Citation Index Expanded (SCI-Expanded) database. Data were extracted from the articles or review articles, and analyzed using CiteSpace and VOSviewer software.</p><p><strong>Results: </strong>A total of 1,895 related studies have been published in 64 countries or regions. The United States has published the most articles, followed by the United Kingdom, Italy, Netherlands, and France. University of Florida (The United States), University of Kansas (The United States), University of Alberta (Canada), University of Cambridge (the United Kingdom), and Dutch Growth Research Foundation (Netherlands) were the top five most productive institutions. Butler, Merlin G. and his colleagues have made the most outstanding contributions in the field of PWS research. Keyword co-occurrence analysis showed that genomic imprinting, uniparental disomy, obesity, hyperphagia, hypothalamus, growth hormone treatment, and ghrelin appeared with the higher frequency. Furthermore, oxytocin, magel2, and management were the latest bursts keywords.</p><p><strong>Conclusion: </strong>Our findings indicated that genetic mechanism, diagnose, and emerging therapies will be the hotspots and frontiers in PWS research.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241058"},"PeriodicalIF":1.7000,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627057/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/med-2024-1058","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Prader-Willi Syndrome (PWS) is a rare disorder that was initially documented by Prader and Willi in 1956. Despite significant advancements in the understanding of PWS over recent decades, no bibliometric studies have been reported on this field. We aimed to analyze and explore the research trends and hotspots of PWS using a bibliometric analysis to understand the future development of basic and clinical research.
Methods: The literature regarding PWS was retrieved from the Web of Science Core Collection Science Citation Index Expanded (SCI-Expanded) database. Data were extracted from the articles or review articles, and analyzed using CiteSpace and VOSviewer software.
Results: A total of 1,895 related studies have been published in 64 countries or regions. The United States has published the most articles, followed by the United Kingdom, Italy, Netherlands, and France. University of Florida (The United States), University of Kansas (The United States), University of Alberta (Canada), University of Cambridge (the United Kingdom), and Dutch Growth Research Foundation (Netherlands) were the top five most productive institutions. Butler, Merlin G. and his colleagues have made the most outstanding contributions in the field of PWS research. Keyword co-occurrence analysis showed that genomic imprinting, uniparental disomy, obesity, hyperphagia, hypothalamus, growth hormone treatment, and ghrelin appeared with the higher frequency. Furthermore, oxytocin, magel2, and management were the latest bursts keywords.
Conclusion: Our findings indicated that genetic mechanism, diagnose, and emerging therapies will be the hotspots and frontiers in PWS research.
背景：Prader-Willi综合征（PWS）是一种罕见的疾病，最初由Prader和Willi于1956年记录。尽管近几十年来对PWS的理解取得了重大进展，但在这一领域还没有文献计量学研究的报道。我们旨在通过文献计量学分析，分析和探讨PWS的研究趋势和热点，了解PWS基础和临床研究的未来发展。方法：从Web of Science核心馆藏科学引文索引扩展（SCI-Expanded）数据库中检索PWS相关文献。从文章或综述文章中提取数据，使用CiteSpace和VOSviewer软件进行分析。结果：在64个国家或地区共发表了1895篇相关研究。美国发表的文章最多，其次是英国、意大利、荷兰和法国。佛罗里达大学（美国）、堪萨斯大学（美国）、阿尔伯塔大学（加拿大）、剑桥大学（英国）和荷兰生长研究基金会（荷兰）是生产力最高的五所大学。Butler, Merlin G.及其同事在PWS研究领域做出了最杰出的贡献。关键词共现分析显示，基因组印迹、单亲二体、肥胖、贪食、下丘脑、生长激素治疗、生长素出现频率较高。此外，催产素、magel2和管理是最新爆发的关键词。结论：PWS的遗传机制、诊断和新兴治疗方法将是PWS研究的热点和前沿。
期刊介绍：
Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.
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