{"title":"Exploring neurosurgical interventions in Alzheimer's disease: current perspectives and future directions.","authors":"Nachammai Kathiresan, Chandrabose Selvaraj, Gowtham Kumar Subbaraj, Kulanthaivel Langeswaran","doi":"10.1007/s10072-024-07925-7","DOIUrl":null,"url":null,"abstract":"<p><p>Alzheimer's Disease (AD), a neurodegenerative disorder characterized by cognitive decline, has traditionally relied on pharmacological interventions. However, the limitations of current treatments have spurred interest in neurosurgical approaches. This review explores the potential of neurosurgery, particularly deep brain stimulation (DBS), in modifying disease progression and enhancing cognitive function in AD patients. While promising, significant challenges, including surgical precision, patient variability, and ethical considerations, hinder widespread application. The future of neurosurgical interventions lies in minimally invasive techniques, novel neurostimulation methods, and precision neurosurgery guided by advanced imaging and neurophysiological mapping. As research advances, neurosurgery may emerge as a valuable tool in the comprehensive management of AD.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"1925-1927"},"PeriodicalIF":2.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurological Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10072-024-07925-7","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/10 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Alzheimer's Disease (AD), a neurodegenerative disorder characterized by cognitive decline, has traditionally relied on pharmacological interventions. However, the limitations of current treatments have spurred interest in neurosurgical approaches. This review explores the potential of neurosurgery, particularly deep brain stimulation (DBS), in modifying disease progression and enhancing cognitive function in AD patients. While promising, significant challenges, including surgical precision, patient variability, and ethical considerations, hinder widespread application. The future of neurosurgical interventions lies in minimally invasive techniques, novel neurostimulation methods, and precision neurosurgery guided by advanced imaging and neurophysiological mapping. As research advances, neurosurgery may emerge as a valuable tool in the comprehensive management of AD.
阿尔茨海默病（AD）是一种以认知能力下降为特征的神经退行性疾病，传统上主要依靠药物干预。然而，目前治疗方法的局限性激发了人们对神经外科方法的兴趣。这篇综述探讨了神经外科，尤其是脑深部刺激（DBS）在改变 AD 患者疾病进展和增强认知功能方面的潜力。虽然前景广阔，但包括手术精确度、患者变异性和伦理考虑在内的重大挑战阻碍了其广泛应用。神经外科干预的未来在于微创技术、新型神经刺激方法以及在先进成像和神经生理学图谱指导下的精确神经外科手术。随着研究的进展，神经外科可能会成为综合治疗 AD 的重要工具。
期刊介绍：
Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.
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