Decreased Memory-Related Regional Cerebral Perfusion in Severe Obstructive Sleep Apnea with a Mild Cognitive Impairment During Wakefulness.

IF 3 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2024-12-03 eCollection Date: 2024-01-01 DOI:10.2147/NSS.S481602

Xiangbo Yan, Wanqing Liu, Danyang Li, Qiang Huang, Jianlin Wu, Qing Zhang

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Abstract

Purpose: Previous studies have found that obstructive sleep apnea (OSA) can induce cognitive impairment (CI). However, the exact mechanisms of CI development in patients with OSA remains unclear. We investigated the neuropathological basis of CI development by examining changes in cerebral blood perfusion.

Patients and methods: Thirty-five patients with untreated OSA (15 with CI and 20 without CI [NCI]) and 15 good sleepers (GS) diagnosed using polysomnography were recruited. All participants underwent resting state brain scans in a Siemens 3.0 Tesla magnetic resonance imaging scanner with a pulsed arterial spin labeling sequence and completed a battery of neuropsychological tests.

Results: Compared to the regional cerebral blood flow (rCBF) values in the GS group, both the CI and NCI groups exhibited lower rCBF values in the bilateral inferior temporal, left lingual, and right medial and paracingulate gyri, as well as higher rCBF values in the bilateral middle frontal gyrus (p < 0.05 in all cases). Compared to the rCBF values in the NCI group, the CI group had lower rCBF values in the bilateral inferior temporal and left lingual gyri, and higher rCBF values in the right rectus and right middle orbital frontal gyri (p < 0.05 in all cases). In the CI group, rCBF values in the bilateral inferior temporal (right, p = 0.025; left, p = 0.005) and left lingual gyri (p = 0.018) were positively associated with the delayed memory scores, and rCBF values in the left inferior temporal gyrus positively correlated with the attention scores (p = 0.011).

Conclusion: Regions with abnormal perfusion in the NCI and CI groups were mostly memory-related. Blood perfusion in the bilateral inferior temporal and left lingual gyri decreased in the following order: GS > OSA-NCI > OSA-CI. These findings provide blood perfusion-level insights into the neuropathological basis of OSA-CI development.

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重度阻塞性睡眠呼吸暂停伴轻度认知障碍患者清醒时记忆相关脑区域灌注减少。

目的：已有研究发现阻塞性睡眠呼吸暂停（OSA）可诱发认知障碍（CI）。然而，阻塞性睡眠呼吸暂停患者CI发展的确切机制尚不清楚。我们通过观察脑血流灌注的变化来探讨脑缺血发作的神经病理学基础。患者和方法：纳入35例未经治疗的OSA患者（15例合并CI， 20例未合并CI [NCI]）和15例采用多导睡眠图诊断的良好睡眠者（GS）。所有参与者都在西门子3.0特斯拉磁共振成像扫描仪上进行了静息状态脑扫描，并进行了脉冲动脉自旋标记序列，并完成了一系列神经心理测试。结果：与GS组相比，CI组和NCI组双侧颞下回、左侧舌回、右侧内侧和扣带旁回区域脑血流（rCBF）值均较低，双侧额叶中回区域脑血流（rCBF）值较高（p < 0.05）。与NCI组相比，CI组双侧颞下回和左侧舌回rCBF值较低，右侧直肌和右侧眶额中回rCBF值较高（均p < 0.05）。CI组双侧颞下区rCBF值(右，p = 0.025；左侧舌回（p = 0.005）和左侧舌回（p = 0.018）与延迟记忆得分呈正相关，左侧颞下回rCBF值与注意得分呈正相关（p = 0.011）。结论：NCI组和CI组灌注异常区域多与记忆相关。双侧颞下回和左侧舌回血流灌注减少的顺序为：GS > OSA-NCI > OSA-CI。这些发现为OSA-CI发展的神经病理学基础提供了血液灌注水平的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.