A new terpestacin-type sesterterpenoid with tricyclic 3/15/5 scaffold from an endophytic fungus Neofusicoccum sp. J019.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-12-09 DOI:10.1080/14786419.2024.2438268

Peishan Gu, Shujie Jia, Zhaolin Chen, Xiao-Nian Li, Yongbo Xue

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引用次数: 0

Abstract

ABSTACTChemical investigation of an endophytic fungus, Neofusicoccum sp. J019, isolated from the plant species Cynanchum chinense R. Br., has led to the identification of an undescribed terpestacin-type sesterterpenoid, neofusistacin (1), together with two analogues (2 and 3). The structure of 1 was elucidated by extensive spectroscopic analyses including UV, IR, 1D, and 2D NMR, HRESIMS, and its absolute configuration was unambiguously confirmed by a single crystal X-ray diffraction analysis. Compound 1 is featured by a rare 3/15/5-fused tricyclic scaffold in terpestacin-type sesterterpenoid. The anti-inflammatory activities of compounds 1-3 were evaluated in vitro, but none of them showed obvious anti-inflammatory activities at the concentration of 100 μM. No antibacterial activity against Escherichia coli ATCC 25922, Salmonella enterica subsp. enterica ATCC 14028, and Staphylococcus aureus subsp. aureus ATCC 29213 was found for compounds 1-3 at the concentration of 100 μM.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.