Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2024-12-03 eCollection Date: 2024-01-01 DOI:10.1515/med-2024-1080

JinXiang Shang, FeiYing Zhao, Lu Xie, YaQing Wang, Bo Li, Cong Jin

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引用次数: 0

Abstract

Background: Osteosarcoma, a highly malignant skeletal tumor, primarily affects children and adolescents. Autophagy plays a crucial role in osteosarcoma pathophysiology. This study utilizes bibliometric analysis to evaluate current research on autophagy in osteosarcoma and forecast future directions.

Methods: We conducted a comprehensive search of publications in the Web of Science Core Collection database from January 1, 2008, to March 15, 2024. Tools like VOSviewer, CiteSpace, R software, Excel, and Scimago were used for analysis and visualization.

Results: Publications increased steadily over 17 years, indicating rising interest. Zhang Yuan was the most influential author, with Shanghai Jiao Tong University leading. Cell Death & Disease was the top journal. "HMGB1 Promotes Drug Resistance in Osteosarcoma" was the most cited paper. Co-cited articles focused on drug resistance, therapeutic targets, autophagy in cancer, and genomic impacts on immunotherapy. Keywords highlighted invasion, migration, cell death, and breast cancer as research hotspots. Future studies will likely focus on therapeutic innovations and integrated management strategies.

Conclusion: This bibliometric analysis offers an overview of current knowledge and emerging trends in autophagy and osteosarcoma, emphasizing key areas like invasion, migration, and cell death. It serves as a valuable resource for researchers developing novel therapies for osteosarcoma.

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背景：骨肉瘤是一种高度恶性的骨骼肿瘤，主要影响儿童和青少年。自噬在骨肉瘤的病理生理学中起着至关重要的作用。本研究利用文献计量学分析评估当前有关骨肉瘤自噬的研究，并预测未来的研究方向：我们对 2008 年 1 月 1 日至 2024 年 3 月 15 日期间在 Web of Science Core Collection 数据库中发表的论文进行了全面检索。我们使用了 VOSviewer、CiteSpace、R 软件、Excel 和 Scimago 等工具进行分析和可视化：结果：17年间，论文发表量稳步增长，表明人们对该研究的兴趣日益浓厚。张远是最有影响力的作者，上海交通大学居首位。细胞死亡与疾病》是顶级期刊。"HMGB1促进骨肉瘤的耐药性 "是被引用次数最多的论文。联合引用的文章主要集中在耐药性、治疗靶点、癌症中的自噬以及基因组对免疫疗法的影响等方面。关键词突出了侵袭、迁移、细胞死亡和乳腺癌等研究热点。未来的研究可能会侧重于治疗创新和综合管理策略：本文献计量分析概述了自噬与骨肉瘤的现有知识和新兴趋势，强调了侵袭、迁移和细胞死亡等关键领域。它是研究人员开发骨肉瘤新型疗法的宝贵资源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.