The Crossroads of Clonal Evolution, Differentiation Hierarchy, and Ontogeny in Leukemia Development.

IF 11.5 Q1 HEMATOLOGY

Blood Cancer Discovery Pub Date : 2025-03-04 DOI:10.1158/2643-3230.BCD-24-0235

Christopher M Sturgeon, Elvin Wagenblast, Franco Izzo, Eirini P Papapetrou

引用次数: 0

Abstract

Significance: In recent years, remarkable technological advances have illuminated aspects of the pathogenesis of myeloid malignancies-yet outcomes for patients with these devastating diseases have not significantly improved. We posit that a synthesized view of the three dimensions through which hematopoietic cells transit during their healthy and diseased life-clonal evolution, stem cell hierarchy, and ontogeny-promises high yields in new insights into disease pathogenesis and new therapeutic avenues.

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白血病发生中克隆进化、分化层次和个体发生的十字路口。

对肿瘤基因组进行大规模和单细胞分辨率测序的变革性技术已经揭示了白血病基因组中存在的一系列遗传改变，以及它们获得的时间和共同发生的模式。与此同时，单细胞多组学技术使我们能够绘制恶性细胞的分化路径和层次结构，并使我们对产前生活中的造血发育有了初步了解。我们提出，利用新的实验系统和多模态技术，研究恶性髓细胞的遗传进化、分化层次和个体发生如何相互交叉，将推动下一代研究突破。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Cancer Discovery Multiple-

CiteScore

12.70

自引率

1.80%

发文量

139

期刊介绍： The journal Blood Cancer Discovery publishes high-quality Research Articles and Briefs that focus on major advances in basic, translational, and clinical research of leukemia, lymphoma, myeloma, and associated diseases. The topics covered include molecular and cellular features of pathogenesis, therapy response and relapse, transcriptional circuits, stem cells, differentiation, microenvironment, metabolism, immunity, mutagenesis, and clonal evolution. These subjects are investigated in both animal disease models and high-dimensional clinical data landscapes. The journal also welcomes submissions on new pharmacological, biological, and living cell therapies, as well as new diagnostic tools. They are interested in prognostic, diagnostic, and pharmacodynamic biomarkers, and computational and machine learning approaches to personalized medicine. The scope of submissions ranges from preclinical proof of concept to clinical trials and real-world evidence. Blood Cancer Discovery serves as a forum for diverse ideas that shape future research directions in hematooncology. In addition to Research Articles and Briefs, the journal also publishes Reviews, Perspectives, and Commentaries on topics of broad interest in the field.