Antioxidant and anti-inflammatory potential of vanillic acid improves nephrotoxicity induced by sodium arsenite in mice.

IF 2.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES
Mohammad Javad Khodayar, Maryam Shirani, Saeedeh Shariati, Layasadat Khorsandi, Shokooh Mohtadi
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引用次数: 0

Abstract

This study examined the potential of vanillic acid (VA) to protect against renal oxidative stress and inflammation caused by sodium arsenite (SA) in mice. Mice were assigned to five groups: control, VA (100 mg/kg), SA (50 ppm in drinking water for 8 weeks), and SA + VA (50 and 100 mg/kg orally in the 7th and 8th weeks). After the experiment was ended, the Mice were sacrificed and serum and renal tissue samples were collected for additional assessments. Treatment with VA suppressed SA-induced increase in blood urea nitrogen and creatinine in the serum. Furthermore, renal histological damage induced by SA administration was ameliorated with VA treatment. Also, the increase in the level of lipid peroxidation marker (thiobarbituric acid reactive substances) along with the reduction in total thiol levels and the diminished activities of antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) in the renal tissue of SA-treated mice were effectively reversed following treatment with VA. The results exhibited that the VA-treated groups (50 and 100 mg/kg) mitigated the elevation of inflammatory markers in kidney tissue (tumor necrosis factor-α and nitric oxide) in SA-exposed mice. Our research findings indicate that VA could be a potential therapeutic agent for the management of SA-associated nephrotoxicity.

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来源期刊
International Journal of Environmental Health Research
International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.70
自引率
3.10%
发文量
134
审稿时长
>12 weeks
期刊介绍: International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.
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