Microneedling and 5-Fluorouracil in Treating Stable Vitiligo in Hitherto Unstudied High Prevalence Population.

IF 1 4区 医学 Q4 DERMATOLOGY
Indian Journal of Dermatology Pub Date : 2024-09-01 Epub Date: 2024-10-29 DOI:10.4103/ijd.ijd_1056_23
B Abhirami, Prabhat Kumar, Dharmendra K Mishra
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引用次数: 0

Abstract

Background: Vitiligo, affecting 0.25% in India (>1% in Jharkhand), stigmatises and devastates self-esteem/relationships causing depression. Apart from medical treatment, surgical procedures like applying 5-fluorouracil after microneedling are to be confirmed in unstudied populations and across time periods. An interventional study was conducted among out-patients of a tertiary hospital in a high-prevalence population wherein earlier attempts were not conducted.

Aims/objectives: To assess the effect of microneedling and applying 5% 5-fluorouracil on stable vitiligo patches.

Methods and materials: Microneedling and topical application of 5-fluorouracil was planned on 30 subjects of 10-50 age-groups with stable vitiligo, from September 2019 to September 2021 every 15 days for 12 visits. Age, gender, site, size/stability of vitiligo patches, leukotrichia and vitiligo family history were studied. Repigmentation (overall and variable-wise) was measured at each visit using 76-100% (excellent), 51-75% (very good), 25 to 50% (good) and <25% (poor). Data was analysed with the Chi-square test or Standard Error of Difference between two proportions.

Results: Under COVID restrictions (2020-2021), sample coverage was 77% (23/30) comprising 13 females and 10 males. Visits varied for each subject totalling 185 visits out of an expected 276 (67%). Significantly, 3 (13%) achieved excellent repigmentation, 10 (43%) very good, 8 (35%) good and only 2 (9%) poor repigmentation. Cumulatively, 13 (56%) attained excellent/very good repigmentation and 21 (91%) had excellent/very good/good repigmentation. Repigmentation ranged from 10% to 100% among 23 subjects, averaging 54% in average 8 visits (4 months). Repigmentation was equally achieved irrespective of age, gender, site, size and stability of the vitiliginous patch, presence/absence of leukotrichia and family history of vitiligo. Manageable pain (100%), itching (4%) and hyperpigmentation 43%, were side effects.

Conclusion: Cumulative 91% (excellent/very good/good) repigmentation despite COVID-19 in the study period, and its comparability with other studies, strengthens evidence that microneedling and 5% 5-fluorouracil is effective in treating stable vitiligo in a high prevalence population.

微针联合5-氟尿嘧啶治疗稳定型白癜风的临床研究。
背景:白癜风在印度的患病率为0.25%(贾坎德邦患病率为1%),它使人蒙受耻辱,破坏自尊/人际关系,导致抑郁。除了医学治疗,外科手术,如在微针后应用5-氟尿嘧啶,将在未研究的人群和不同时期得到证实。在一家三级医院的高患病率人群的门诊病人中进行了一项介入性研究,其中早期的尝试没有进行。目的:评价微针加5% 5-氟尿嘧啶治疗稳定型白癜风贴片的疗效。方法与材料:计划于2019年9月至2021年9月对30例10 ~ 50岁年龄段的稳定型白癜风患者进行5-氟尿嘧啶微针外敷,每15天进行12次就诊。研究对象包括年龄、性别、部位、白癜风斑块大小/稳定性、白斑病和白癜风家族史。在每次访问时,使用76-100%(优秀)、51-75%(非常好)、25 - 50%(良好)来测量色素沉着(总体和变量方面)。结果:在COVID限制(2020-2021)下,样本覆盖率为77%(23/30),包括13名女性和10名男性。每个受试者的访问次数各不相同,在预期的276次访问中,共有185次访问(67%)。值得注意的是,3例(13%)获得了良好的色素沉着,10例(43%)非常好,8例(35%)良好,只有2例(9%)较差。累计13例(56%)获得优秀/非常好的色素沉着,21例(91%)获得优秀/非常好/良好的色素沉着。在23名受试者中,平均8次复诊(4个月)中,色素沉着率从10%到100%不等,平均为54%。无论年龄、性别、部位、白癜风斑块的大小和稳定性、白斑病的存在与否和白癜风家族史如何,都能同样实现色素再生。可控制的疼痛(100%),瘙痒(4%)和色素沉着(43%)是副作用。结论:在研究期间,尽管有COVID-19,但累计有91%(优秀/非常好/良好)的再色素沉着,并且与其他研究具有可比性,这加强了微针和5% 5-氟尿嘧啶治疗高患病率人群稳定型白癜风的有效证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Indian Journal of Dermatology
Indian Journal of Dermatology Medicine-Dermatology
CiteScore
1.80
自引率
0.00%
发文量
217
审稿时长
47 weeks
期刊介绍: The journal publishes information related to skin-pathology and different modes of therapeutics, including dermatosurgery and cosmetic dermatology. Likewise, it carries articles on leprosy, STI and HIV/AIDS. The editorial board encourages the authors to publish articles addressing emerging techniques and developments in the subject specialty, in the form of Original investigations, Narrative and Systematic Reviews as well as Case Reports. The journal aims at publishing Editorials and Commentaries from eminent personalities on a regular basis.
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