Triglycerides and HDL Cholesterol Mediate the Association Between Waist Circumference and Hyperuricemia in Normal-Weight Men.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2024-12-01 eCollection Date: 2024-01-01 DOI:10.2147/DMSO.S493327

Wen-Xia Cui, Shi-Wen Wang, Lei Gao, Ding-Huang Mu, Nan Li, Feng-Hui Pan, Wei-Hong Zhou, Yun Hu

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引用次数: 0

Abstract

Purpose: Hyperuricemia has traditionally been associated with obesity and dyslipidemia. However, the relationship between waist circumference (WC) and hyperuricemia in normal-weight men is still unclear, particularly regarding the roles of triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C). The aim of this research was to explore the mediating roles of TG and HDL-C in the association between WC and hyperuricemia in normal-weight men.

Methods: A retrospective observational study was conducted among normal-weight men (18.5 ≤ BMI < 24 kg/m²) aged ≥ 18 years who underwent health checkups in Nanjing from 2021-2023. Relationships between WC, blood lipids, and hyperuricemia were investigated by multivariable regression models and mediation analysis.

Results: We enrolled 35,984 participants, with an overall hyperuricemia prevalence of 24.2%. The research found a significant positive association between WC and hyperuricemia in normal-weight men (P < 0.001). For hyperuricemia across rising WC quartiles, with WC divided as follows: Q1 (59 ≤ WC < 77 cm), Q2 (77 ≤ WC < 81 cm), Q3 (81 ≤ WC < 85 cm), and Q4 (85 ≤ WC ≤ 107 cm), the multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were 1.00 (reference), 1.09 (1.01, 1.18), 1.26 (1.15, 1.37), and 1.34 (1.22, 1.46), respectively (all P < 0.001). The mediation analysis indicated that WC had a significant total effect on hyperuricemia (Coefficient = 0.0046, 95% CI: 0.0028, 0.0070, P < 0.001), with significant indirect effects mediated through TG and HDL-C, contributing mediation proportions of 22.3% and 18.3%, respectively (both P < 0.05).

Conclusion: Elevated WC is associated with an increased likelihood of hyperuricemia in normal-weight men. TG and HDL-C play substantial mediating roles in this association. These findings suggest that monitoring WC and lipid profiles in normal-weight men could help identify those at higher risk of hyperuricemia, even in the absence of general obesity.

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甘油三酯和高密度脂蛋白胆固醇介导正常体重男性腰围和高尿酸血症之间的关系

目的：高尿酸血症传统上与肥胖和血脂异常有关。然而，在正常体重的男性中，腰围（WC）和高尿酸血症之间的关系仍然不清楚，特别是关于甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）的作用。本研究的目的是探讨TG和HDL-C在正常体重男性WC和高尿酸血症之间的中介作用。方法：对南京市2021-2023年健康体检年龄≥18岁的正常体重（18.5≤BMI < 24 kg/m2）男性进行回顾性观察研究。通过多变量回归模型和中介分析来研究WC、血脂和高尿酸血症之间的关系。结果：我们招募了35,984名参与者，总体高尿酸血症患病率为24.2%。研究发现，体重正常的男性WC与高尿酸血症之间存在显著正相关（P < 0.001）。对于升高的腰围四分位数的高尿酸血症，腰围分为：Q1（59≤腰围< 77厘米），Q2（77≤腰围< 81厘米），Q3（81≤腰围< 85厘米）和Q4（85≤腰围≤107厘米），多变量调整比值比（or）和95%置信区间（ci）分别为1.00（参考），1.09(1.01,1.18),1.26（1.15,1.37）和1.34(1.22,1.46)（均P < 0.001）。中介分析表明，WC对高尿酸血症有显著的总效应（系数= 0.0046,95% CI: 0.0028, 0.0070, P < 0.001），通过TG和HDL-C介导的间接效应显著，中介比例分别为22.3%和18.3% （P < 0.05）。结论：在体重正常的男性中，WC升高与高尿酸血症的可能性增加有关。TG和HDL-C在这一关联中起重要的中介作用。这些发现表明，监测体重正常的男性的WC和脂质特征可以帮助识别高尿酸血症的高风险人群，即使没有普遍肥胖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.