G protein-coupled receptor-receptor interactions in gonadal physiology.

IF 3.2 2区医学 Q1 ANDROLOGY

Andrology Pub Date : 2024-12-09 DOI:10.1111/andr.13821

Clara Lazzaretti, Mohammed Akli Ayoub, Livio Casarini

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引用次数: 0

Abstract

Background: Gonadotropins are glycoprotein hormones fundamental in the endocrine regulation of reproduction. They act on structurally similar members of G protein-coupled receptors (GPCRs) expressed exclusively in the gonads and support gametogenesis, sex steroid synthesis, and pregnancy. While it is a common opinion that the gonadotropin receptors act as a single molecule entity (monomer), increasing evidence underlines the formation of molecular complexes involving multiple receptors.

Objectives: To review current knowledge of membrane receptor-receptor interactions in reproduction.

Results and discussion: Homo/heteromers of gonadotropin receptors may act as allosteric modulators, act as biased agonist and/or cooperate in sustaining intracellular signals fundamental to support reproduction. Technical limitations lead to in vitro data that require to be confirmed in vivo to figure out the physiological impact of gonadotropin receptor assemblies.

Conclusions: Gonadotropin receptor homo/heteromers provide a new field of research that deserves attention for possible clinical and therapeutic implications in physiology and pathophysiology.

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来源期刊

Andrology ANDROLOGY-

CiteScore

9.10

自引率

6.70%

发文量

200

期刊介绍： Andrology is the study of the male reproductive system and other male gender related health issues. Andrology deals with basic and clinical aspects of the male reproductive system (gonads, endocrine and accessory organs) in all species, including the diagnosis and treatment of medical problems associated with sexual development, infertility, sexual dysfunction, sex hormone action and other urological problems. In medicine, Andrology as a specialty is a recent development, as it had previously been considered a subspecialty of urology or endocrinology