{"title":"Life-Threatening Ventricular Tachyarrhythmia in Isolated Cardiac Sarcoidosis Compared With Cardiac Sarcoidosis With Extracardiac Involvement.","authors":"Yoichi Takaya, Koji Nakagawa, Toru Miyoshi, Nobuhiro Nishii, Hiroshi Morita, Kazufumi Nakamura, Shinsuke Yuasa","doi":"10.1016/j.amjcard.2024.12.002","DOIUrl":null,"url":null,"abstract":"<p><p>Although isolated cardiac sarcoidosis (CS) is not uncommon, little is known about the risk of life-threatening ventricular tachyarrhythmia. We aimed to evaluate the incidence of ventricular tachyarrhythmia in patients with isolated CS. Ninety-four patients with CS were enrolled. Isolated CS was diagnosed by histological or clinical confirmation in the heart alone. The endpoint was sudden cardiac death, ventricular fibrillation, sustained ventricular tachycardia, or implantable cardioverter defibrillator (ICD) therapy for ventricular fibrillation or sustained ventricular tachycardia. Twenty-five patients were diagnosed with isolated CS, and 69 with CS with extracardiac involvement. As the initial cardiac manifestation leading to the CS diagnosis, 10 (40%) patients with isolated CS had ventricular tachyarrhythmia. Over the median follow-up of 48 months after the CS diagnosis, sudden cardiac death occurred in 2 (8%) patients with isolated CS. Ventricular fibrillation or sustained ventricular tachycardia, including ICD therapy, occurred in 15 (60%) patients with isolated CS and 13 (19%) with CS with extracardiac involvement. The rate of ventricular tachyarrhythmia was higher in patients with isolated CS than in those with CS with extracardiac involvement (log-rank, p < 0.01). Cox proportional hazard analysis showed that isolated CS was independently associated with ventricular tachyarrhythmia. Two or more ventricular tachyarrhythmias more frequently occurred in patients with isolated CS (52% vs 13%, p < 0.01). Electric storm more frequently occurred in patients with isolated CS (24% vs 6%, p = 0.01). In conclusion, patients with isolated CS have ventricular tachyarrhythmia at a higher rate, compared with those with CS with extracardiac involvement.</p>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.amjcard.2024.12.002","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Although isolated cardiac sarcoidosis (CS) is not uncommon, little is known about the risk of life-threatening ventricular tachyarrhythmia. We aimed to evaluate the incidence of ventricular tachyarrhythmia in patients with isolated CS. Ninety-four patients with CS were enrolled. Isolated CS was diagnosed by histological or clinical confirmation in the heart alone. The endpoint was sudden cardiac death, ventricular fibrillation, sustained ventricular tachycardia, or implantable cardioverter defibrillator (ICD) therapy for ventricular fibrillation or sustained ventricular tachycardia. Twenty-five patients were diagnosed with isolated CS, and 69 with CS with extracardiac involvement. As the initial cardiac manifestation leading to the CS diagnosis, 10 (40%) patients with isolated CS had ventricular tachyarrhythmia. Over the median follow-up of 48 months after the CS diagnosis, sudden cardiac death occurred in 2 (8%) patients with isolated CS. Ventricular fibrillation or sustained ventricular tachycardia, including ICD therapy, occurred in 15 (60%) patients with isolated CS and 13 (19%) with CS with extracardiac involvement. The rate of ventricular tachyarrhythmia was higher in patients with isolated CS than in those with CS with extracardiac involvement (log-rank, p < 0.01). Cox proportional hazard analysis showed that isolated CS was independently associated with ventricular tachyarrhythmia. Two or more ventricular tachyarrhythmias more frequently occurred in patients with isolated CS (52% vs 13%, p < 0.01). Electric storm more frequently occurred in patients with isolated CS (24% vs 6%, p = 0.01). In conclusion, patients with isolated CS have ventricular tachyarrhythmia at a higher rate, compared with those with CS with extracardiac involvement.
期刊介绍:
Published 24 times a year, The American Journal of Cardiology® is an independent journal designed for cardiovascular disease specialists and internists with a subspecialty in cardiology throughout the world. AJC is an independent, scientific, peer-reviewed journal of original articles that focus on the practical, clinical approach to the diagnosis and treatment of cardiovascular disease. AJC has one of the fastest acceptance to publication times in Cardiology. Features report on systemic hypertension, methodology, drugs, pacing, arrhythmia, preventive cardiology, congestive heart failure, valvular heart disease, congenital heart disease, and cardiomyopathy. Also included are editorials, readers'' comments, and symposia.