Harnessing Nanomaterials for Enhanced DNA-Based Biosensing and Therapeutic Performance

IF 2.6 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
ChemBioChem Pub Date : 2024-12-10 DOI:10.1002/cbic.202400936
Xumin Pan, Xiaoman Zhao, Yanhong Lu, Ping Xie, Lan Liu, Xia Chu
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引用次数: 0

Abstract

The integration of nanomaterials with DNA-based systems has emerged as a transformative approach in biosensing and therapeutic applications. Unique features of DNA, like its programmability and specificity, complement the diverse functions of nanomaterials, leading to the creation of advanced systems for detecting biomarkers and delivering treatments. Here, we review the developments in DNA-nanomaterial conjugates, emphasizing their enhanced functionalities and potential across various biomedical applications. We first discuss the methodologies for synthesizing these conjugates, distinguishing between covalent and non-covalent interactions. We then categorize DNA-nanomaterials conjugates based on the properties of the DNA and nanomaterials involved, respectively. DNA probes are classified by their application into biosensing or therapeutic uses, and, several nanomaterials are highlighted by their recent progress in living biological. Finally, we discuss the current challenges and future prospects in this field, anticipating that significant progress in DNA-nanomaterial conjugates will greatly enhance precision medicine.

Abstract Image

利用纳米材料增强基于dna的生物传感和治疗性能。
纳米材料与基于dna的系统的整合已经成为生物传感和治疗应用的一种变革性方法。DNA的独特特性,如可编程性和特异性,补充了纳米材料的各种功能,从而创造了检测生物标志物和提供治疗的先进系统。在这里,我们回顾了dna -纳米材料缀合物的发展,强调了它们在各种生物医学应用中的增强功能和潜力。我们首先讨论了合成这些共轭物的方法,区分了共价和非共价相互作用。然后,我们分别根据DNA和纳米材料的性质对DNA-纳米材料缀合物进行分类。DNA探针根据其在生物传感和治疗方面的应用而被分类,近年来,一些纳米材料在活生物领域的进展备受关注。最后,我们讨论了该领域目前面临的挑战和未来的前景,并预测dna -纳米材料偶联物的重大进展将大大提高精准医学的水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ChemBioChem
ChemBioChem 生物-生化与分子生物学
CiteScore
6.10
自引率
3.10%
发文量
407
审稿时长
1 months
期刊介绍: ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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