β-halovinyl Aldehydes: Multifaceted Versatile Building Blocks in Organic Synthesis

Abstract

β-halovinyl aldehydes serve as a valuable building blocks in organic synthesis. These aldo-x bifunctional building blocks (AXB3s) contain a alkenic double bond (vinyl) as well as a formyl group along with a halogen atom (Cl, Br, I) bonded with the β-carbon atom of vinyl aldehyde. Owing to the presence of these multiple reactive sites, β-halovinyl aldehydes act as a suitable precursor for Michael addition, direct addition, cross-coupling reactions, condensation reactions, nucleophilic substitution reactions, domino reactions, MCRs, Diels-Alder reaction, functional group transformation reactions and enantioslective transformations. Therefore, a comprehensive review on synthetic exploration of β-halovinyl aldehydes has been carried out for the generation of reactive intermediates and diverse bioactives heterocycles by using various C-C, C-N, C-S and C-O bond forming reactions. In this review, we have assembled the literature from mid-2007 to Jan 2024.