{"title":"Raman spectroscopic technologies for chiral discrimination: Current status and new frontiers","authors":"Yu Tian, Ge Fang, Fengxia Wu, Juliana Gaithan Kauno, Haili Wei, Hsien-Yi Hsu, Fenghua Li, Guobao Xu, Wenxin Niu","doi":"10.1016/j.ccr.2024.216375","DOIUrl":null,"url":null,"abstract":"Chiral discrimination is crucial in drug safety, catalysis, materials science, and environmental sustainability, as enantiomers often exhibit distinct biological, chemical, and physical properties. Raman spectroscopic technologies have established efficient strategies for discriminating enantiomers through manipulating the Raman excitation and scattering light, as well as constructing chiral molecular recognition systems and chiral surface-enhanced Raman spectroscopy (SERS) substrates, which offer the advantages of non-destructive, label-free, and real-time analysis. This review systematically summarizes the principles and recent advances in Raman spectroscopic technologies for discriminating enantiomers. We begin by introducing the fundamental mechanisms and experimental progress of Raman optical activity (ROA), highlighting its importance in enantiomeric discrimination. Moving beyond the complex instruments used in ROA-based methods, we discuss critical breakthroughs in enantiomeric discrimination by combining plasmonic structures with conventional Raman spectrometers. The emerging strategies to discriminate enantiomers by both achiral and chiral plasmonic structures are summarized, with particular emphasis on the underlying mechanisms of chiral plasmonic structures in enantioselective SERS. Finally, we present the major challenges and future opportunities in this evolving field, providing insights into the future development directions.","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"21 1","pages":""},"PeriodicalIF":20.3000,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coordination Chemistry Reviews","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.ccr.2024.216375","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
Chiral discrimination is crucial in drug safety, catalysis, materials science, and environmental sustainability, as enantiomers often exhibit distinct biological, chemical, and physical properties. Raman spectroscopic technologies have established efficient strategies for discriminating enantiomers through manipulating the Raman excitation and scattering light, as well as constructing chiral molecular recognition systems and chiral surface-enhanced Raman spectroscopy (SERS) substrates, which offer the advantages of non-destructive, label-free, and real-time analysis. This review systematically summarizes the principles and recent advances in Raman spectroscopic technologies for discriminating enantiomers. We begin by introducing the fundamental mechanisms and experimental progress of Raman optical activity (ROA), highlighting its importance in enantiomeric discrimination. Moving beyond the complex instruments used in ROA-based methods, we discuss critical breakthroughs in enantiomeric discrimination by combining plasmonic structures with conventional Raman spectrometers. The emerging strategies to discriminate enantiomers by both achiral and chiral plasmonic structures are summarized, with particular emphasis on the underlying mechanisms of chiral plasmonic structures in enantioselective SERS. Finally, we present the major challenges and future opportunities in this evolving field, providing insights into the future development directions.
期刊介绍:
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.