Treatment trajectories among children and adolescents referred to the Norwegian National Center for Gender Incongruence

IF 2.4 4区 医学 Q1 PEDIATRICS
Acta Paediatrica Pub Date : 2024-12-08 DOI:10.1111/apa.17530
Cecilie Bjertness Nyquist, Leila Torgersen, Linda W. David, Trond Haaken Diseth, Kjersti Gulbrandsen, Anne Waehre
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Abstract

Aim

We aimed to describe treatment trajectories, detransition and mortality rate among children and adolescents referred to the Norwegian National Center for Gender Incongruence (NCGI).

Methods

The cohort included all 1258 persons under 18 years at referral to the NCGI from 2000 to 2020. Trajectories were registered until end of 2023.

Results

In total, 861/1258 (68.4%) were assigned female gender at birth (AFAB). Mean age at referral was 14.4 years. Puberty suppression with gonadotropin-releasing hormone agonists (GnRHa) was initiated among 135/1258 (10.7%), significantly more persons assigned male gender at birth (AMAB) than AFAB (p < 0.001). Gender-affirming hormonal treatment (GAHT) was initiated in 783/1258 (62.2%). The continuation rate from GnRHa to GAHT was 97%. Discharge rate from NCGI without gender-affirming medical treatment among those who attended at least one appointment, was 264/1198 (22.0%). Eighteen AFAB detransitioned after initiated GAHT, eleven due to a cessation of transgender identity. Mortality rate in the cohort until end of 2023 was 11/1258 (0.9%).

Conclusion

Different trajectories including medical pathways and assessments without gender-affirming treatment were observed. GAHT was initiated in 783/1258 (62.2%), including eighteen AFAB detransitioning after testosterone treatment. There was a high continuation rate from GnRHa to GAHT. Various trajectories highlights the need for long-term follow-up in care.

Abstract Image

儿童和青少年的治疗轨迹参考挪威国家性别不一致中心。
目的:我们旨在描述转诊至挪威国家性别不协调中心(NCGI)的儿童和青少年的治疗轨迹、转院情况和死亡率:研究对象包括2000年至2020年期间转诊至挪威国家性别不协调中心的所有1258名18岁以下的患者。结果:总共有 861/1258 人(861/1258 人)(占总人数的 25%)患有性别不协调症:共有 861/1258 人(68.4%)在出生时被指定为女性(AFAB)。转诊时的平均年龄为 14.4 岁。135/1258(10.7%)人开始使用促性腺激素释放激素激动剂(GnRHa)抑制青春期发育,其中出生时性别为男性(AMAB)的人数明显多于出生时性别为女性(AFAB)的人数(P 结论:在转诊过程中,医疗路径和治疗方法的不同轨迹可能会导致不同的结果:观察到了不同的发展轨迹,包括医疗途径和未进行性别确认治疗的评估。783/1258(62.2%)人开始接受性别确认治疗,其中包括 18 名在睾酮治疗后脱离性别确认治疗的 AFAB 患者。从 GnRHa 到 GAHT 的持续率很高。不同的治疗轨迹凸显了长期跟踪护理的必要性。
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来源期刊
Acta Paediatrica
Acta Paediatrica 医学-小儿科
CiteScore
6.50
自引率
5.30%
发文量
384
审稿时长
2-4 weeks
期刊介绍: Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries
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