Collective mechanics of small migrating cell groups.

Abstract

Migration of adhesive cell groups is a fundamental part of wound healing, development and carcinogenesis. Intense research has been conducted on mechanisms of collective migration of adhesive groups of cells. Here we focus on mechanical and mechanistic lessons from small migrating cell groups. We review forces and locomotory dynamics of two- and three-cell clusters, rotation of cell doublets, self-organization of one-dimensional cell trains, nascent efforts to understand three-dimensional collective migration and border cell clusters in Drosophila embryo.