Exosomes and tumor virus interlink: A complex side of cancer

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2025-02-01 DOI:10.1016/j.prp.2024.155747

Ibrahim S. Topiwala , Aparna Ramachandran , Meghana Shakthi A , Ranjini Sengupta , Rajib Dhar , Arikketh Devi

引用次数: 0

Abstract

Extracellular Vesicles (EVs) based cancer research reveals several complicated sides of cancer. EVs are classified as several subpopulations such as microvesicles, apoptotic bodies, and exosomes. In cancer, exosomes play a significant role as a cellular messenger in tumor development and progression. Tumor-derived exosomes (TEXs) are also a theranostic tool for cancer. Tumor virus-infected cell-derived EVs promote cancer development. Exosomes (a subpopulation of EVs) play a significant role in converting noninfecting cells to infected cells. It transports several biological active cargo (DNA, RNA, protein, and virions) towards the noninfected cells. This cellular transport enhances infection rates via reprogramming of noninfected cells. In this review, we explore tumor viruses, exosomes and tumor viruses interlink, the theranostic landscape of exosomes in tumor virus-associated cancer and the future orientation of exosomes-based virus oncology.

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外泌体和肿瘤病毒的相互联系：癌症复杂的一面。

基于细胞外囊泡（EVs）的癌症研究揭示了癌症的几个复杂方面。ev可分为几个亚群，如微囊泡、凋亡小体和外泌体。在癌症中，外泌体作为细胞信使在肿瘤的发生和发展中起着重要的作用。肿瘤源性外泌体（TEXs）也是一种治疗癌症的工具。肿瘤病毒感染的细胞衍生的ev促进癌症的发展。外泌体（ev的一个亚群）在将非感染细胞转化为感染细胞方面起着重要作用。它向未感染的细胞运送几种生物活性货物（DNA、RNA、蛋白质和病毒粒子）。这种细胞转运通过对未感染细胞的重编程提高了感染率。本文综述了肿瘤病毒、外泌体和肿瘤病毒的相互联系、外泌体在肿瘤病毒相关癌症中的治疗前景以及基于外泌体的病毒肿瘤学的未来发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.