Interleaved flow-sensitive dephasing (iFSD): Toward enhanced blood flow suppression and preserved T1 weighting and overall signals in 3D TSE-based neuroimaging.
IF 3 3区 医学Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Qingle Kong, Jiayu Xiao, Mark S Shiroishi, Nasim Sheikh-Bahaei, Steven Y Cen, Kasra Khatibi, William J Mack, Jason C Ye, Paul E Kim, Xiaoming Bi, David Saloner, Qi Yang, Eric Chang, Zhaoyang Fan
{"title":"Interleaved flow-sensitive dephasing (iFSD): Toward enhanced blood flow suppression and preserved T<sub>1</sub> weighting and overall signals in 3D TSE-based neuroimaging.","authors":"Qingle Kong, Jiayu Xiao, Mark S Shiroishi, Nasim Sheikh-Bahaei, Steven Y Cen, Kasra Khatibi, William J Mack, Jason C Ye, Paul E Kim, Xiaoming Bi, David Saloner, Qi Yang, Eric Chang, Zhaoyang Fan","doi":"10.1002/mrm.30391","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To develop and validate a 3D turbo spin-echo (TSE)-compatible approach to enhancing black-blood (BB) effects while preserving T<sub>1</sub> weighting and overall SNR.</p><p><strong>Methods: </strong>Following the excitation RF pulse, a 180° RF pulse sandwiched by a pair of flow-sensitive dephasing (FSD) gradient pulses in the phase- (y) and partition-encoding (z) directions, respectively, is added. The polarity of FSD gradients in z direction is toggled every TR, achieving an interleaved FSD (iFSD) configuration in y-z plane. The technique was optimized and evaluated in 18 healthy volunteers and 32 patients with neurovascular disease or brain metastases. Comparisons were made among TSE with and without one of BB preparations: iFSD, delay alternating with nutation for tailored excitation, and motion-sensitized driven equilibrium.</p><p><strong>Results: </strong>iFSD-TSE achieved the best blood flow suppression indicated by venous sinus SNR and parenchyma-to-sinus contrast-to-noise ratio (CNR). iFSD-TSE yielded slightly lower white matter SNR (106.6 ± 32.9) and white-to-gray matter CNR (27.3 ± 8.1) compared to TSE (111.4 ± 31.5 and 28.6 ± 8.8), which were significantly higher than those of delay alternating with nutation for tailored excitation-prepared TSE (84.3 ± 25.0 and 16.8 ± 4.8) and motion-sensitized driven equilibrium-prepared TSE (77.3 ± 26.6 and 15.9 ± 5.3). At the neurovascular wall lesions, iFSD-TSE yielded the highest wall-to-lumen CNR among the three sequences with a BB preparation, all of which significantly outperformed TSE. iFSD-TSE effectively suppressed slow-flow artifacts that otherwise mimicked an atherosclerotic lesion or strongly contrast-enhancing vessel wall. In diagnosing brain metastases, iFSD allowed for highest inter-reader agreement (κ 0.75) and shortest reading time.</p><p><strong>Conclusion: </strong>iFSD is a promising approach compatible with 3D TSE for robust blood flow suppression and preserved T<sub>1</sub> weighting and overall SNR.</p>","PeriodicalId":18065,"journal":{"name":"Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Magnetic Resonance in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/mrm.30391","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: To develop and validate a 3D turbo spin-echo (TSE)-compatible approach to enhancing black-blood (BB) effects while preserving T1 weighting and overall SNR.
Methods: Following the excitation RF pulse, a 180° RF pulse sandwiched by a pair of flow-sensitive dephasing (FSD) gradient pulses in the phase- (y) and partition-encoding (z) directions, respectively, is added. The polarity of FSD gradients in z direction is toggled every TR, achieving an interleaved FSD (iFSD) configuration in y-z plane. The technique was optimized and evaluated in 18 healthy volunteers and 32 patients with neurovascular disease or brain metastases. Comparisons were made among TSE with and without one of BB preparations: iFSD, delay alternating with nutation for tailored excitation, and motion-sensitized driven equilibrium.
Results: iFSD-TSE achieved the best blood flow suppression indicated by venous sinus SNR and parenchyma-to-sinus contrast-to-noise ratio (CNR). iFSD-TSE yielded slightly lower white matter SNR (106.6 ± 32.9) and white-to-gray matter CNR (27.3 ± 8.1) compared to TSE (111.4 ± 31.5 and 28.6 ± 8.8), which were significantly higher than those of delay alternating with nutation for tailored excitation-prepared TSE (84.3 ± 25.0 and 16.8 ± 4.8) and motion-sensitized driven equilibrium-prepared TSE (77.3 ± 26.6 and 15.9 ± 5.3). At the neurovascular wall lesions, iFSD-TSE yielded the highest wall-to-lumen CNR among the three sequences with a BB preparation, all of which significantly outperformed TSE. iFSD-TSE effectively suppressed slow-flow artifacts that otherwise mimicked an atherosclerotic lesion or strongly contrast-enhancing vessel wall. In diagnosing brain metastases, iFSD allowed for highest inter-reader agreement (κ 0.75) and shortest reading time.
Conclusion: iFSD is a promising approach compatible with 3D TSE for robust blood flow suppression and preserved T1 weighting and overall SNR.
期刊介绍：
Magnetic Resonance in Medicine (Magn Reson Med) is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications. Reports of original investigations in the areas of mathematics, computing, engineering, physics, biophysics, chemistry, biochemistry, and physiology directly relevant to magnetic resonance will be accepted, as well as methodology-oriented clinical studies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
