Quantitative assessment of thalamic damage and serum neurofilament light chain in relapsing-remitting multiple sclerosis

IF 2.9 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2024-12-04 DOI:10.1016/j.jneuroim.2024.578504

Yan Liang , Jing Huang , Xiyue Zhang , Fang Xu , Chunrui Bo , Ming Lin , Xinmei Wen

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Abstract

Background

The study assessed group differences in the thalamus microstructural parameters among healthy individuals and relapsing-remitting multiple sclerosis (RRMS) patients and examined the relationship between quantitative MRI (qMRI) parameters and neurological scores, T2 lesion load, and serum neurofilament light chain (sNfL) levels.

Methods

A total of 30 patients with RRMS and 26 age- and sex-matched healthy controls were recruited in this study. The qMRI images were obtained from these individuals. T2 lesion load, thalamic volume, and parameters of thalamic subnuclei were estimated. The neurological functions of participants were assessed using a battery of tests. sNfL concentrations were measured using the single molecule array (SIMOA) technique.

Results

T2 relaxometry in the whole thalamus and its subnuclei were increased, and showed an apparent correlation with T2 lesion load and the severity of MS (EDSS, MSSS, 9HPT, T25FW, SDMT). T1 variability was prolonged in most thalamic subnuclei, and it was correlated with the severity of MS (EDSS, 9HPT, SDMT). Thalamic volumetric parameters of MS patients were smaller than those of healthy controls (p < 0.001) and showed an apparent correlation with MS severity. Surprisingly, sNfL levels showed no correlation with T2 relaxometry, T1 variability, or thalamic volumetric parameters.

Conclusion

Quantitative synthetic MRI, especially, the metric T2 relaxation times provides a surrogate parameter for assessing underlying thalamic and subnuclei damage in the RRMS group. Integrating structural and quantitative MRI allows a better assessment of the neurodegeneration in the normal-appearing thalamus of RRMS.

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复发-缓解型多发性硬化症丘脑损伤及血清神经丝轻链定量评价。

背景：本研究评估了健康个体和复发-缓解型多发性硬化症（RRMS）患者丘脑微结构参数的组间差异，并研究了定量MRI （qMRI）参数与神经学评分、T2病变负荷和血清神经丝轻链（sNfL）水平之间的关系。方法：本研究共招募了30例RRMS患者和26例年龄和性别匹配的健康对照。从这些个体获得qMRI图像。评估T2病变负荷、丘脑体积和丘脑亚核参数。参与者的神经功能通过一系列测试进行评估。采用单分子阵列（SIMOA）技术测定sNfL浓度。结果：整个丘脑及其亚核T2松弛测量值升高，且与T2病变负荷及MS严重程度（EDSS、MSSS、9HPT、T25FW、SDMT）呈明显相关。T1变异性在大多数丘脑亚核中延长，并且与MS的严重程度相关（EDSS, 9HPT， SDMT）。结论：定量合成MRI，特别是T2弛豫时间，为评估RRMS组丘脑和亚核潜在损伤提供了替代参数。结合结构和定量MRI可以更好地评估RRMS正常丘脑的神经退行性变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.