Isabel R Barnet, Noah E Schulz, Sunil J Ghelani, David M Hoganson, Eric N Feins, Peter E Hammer, Sitaram M Emani, Lynn A Sleeper, Rebecca S Beroukhim
{"title":"Wide Variation in Shape of Hypoplastic Left Ventricles Undergoing Recruitment and Biventricular Repair: A Statistical Shape Modeling Study.","authors":"Isabel R Barnet, Noah E Schulz, Sunil J Ghelani, David M Hoganson, Eric N Feins, Peter E Hammer, Sitaram M Emani, Lynn A Sleeper, Rebecca S Beroukhim","doi":"10.1016/j.jocmr.2024.101131","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Patients with hypoplastic left ventricles (LV) who undergo volume-loading procedures (recruitment, biventricular (BIV) repair) are at risk for adverse outcomes including heart failure and death. We investigated pre-BIV LV shape as a predictor of outcome after BIV repair in patients with hypoplastic LVs.</p><p><strong>Methods: </strong>Baseline and post-recruitment cardiac MRI and CT data were analyzed in patients with hypoplastic LV (< 50 ml/m<sup>2</sup>). Statistical shape modeling (SSM) was utilized to generate a model of the shape and variability of LVs. Traditional measures of LV sphericity and eccentricity were also measured. Major adverse cardiac events (MACE) included heart failure, transplant, and death.</p><p><strong>Results: </strong>Of 95 patients with baseline mean LV volume 29 ± 13ml/m<sup>2</sup>, 45 (47%) had a right dominant atrioventricular canal defect, 31 (34%) had a variant of hypoplastic left heart syndrome, and 18 (19%) had endocardial fibroelastosis (EFE). A wide variation in LV shape was found by SSM, and shape modes were associated with RV and LV size, and diagnosis. BIV repair was achieved in 74 (78%) patients; and 13 (18%) of BIV patients had MACE. Predictors of MACE following BIV repair included EFE, higher RV mass index, and higher RV end-diastolic volume index. No baseline or post-recruitment LV shape parameter was associated with outcome after BIV repair.</p><p><strong>Conclusions: </strong>The shape model of hypoplastic LVs demonstrated a wide array of LV shapes. LVs gained sphericity and size and lost eccentricity with recruitment. Though the ventricles changed shape with recruitment, no specific LV shape characteristic at the baseline or post-recruitment stage was predictive of decision to proceed with BIV repair nor outcome. Higher RV mass and volume may represent new biomarkers that predict outcome following BIV repair in patients with hypoplastic LV. Further investigation could determine the reproducibility of these findings.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101131"},"PeriodicalIF":4.2000,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cardiovascular Magnetic Resonance","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jocmr.2024.101131","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Patients with hypoplastic left ventricles (LV) who undergo volume-loading procedures (recruitment, biventricular (BIV) repair) are at risk for adverse outcomes including heart failure and death. We investigated pre-BIV LV shape as a predictor of outcome after BIV repair in patients with hypoplastic LVs.
Methods: Baseline and post-recruitment cardiac MRI and CT data were analyzed in patients with hypoplastic LV (< 50 ml/m2). Statistical shape modeling (SSM) was utilized to generate a model of the shape and variability of LVs. Traditional measures of LV sphericity and eccentricity were also measured. Major adverse cardiac events (MACE) included heart failure, transplant, and death.
Results: Of 95 patients with baseline mean LV volume 29 ± 13ml/m2, 45 (47%) had a right dominant atrioventricular canal defect, 31 (34%) had a variant of hypoplastic left heart syndrome, and 18 (19%) had endocardial fibroelastosis (EFE). A wide variation in LV shape was found by SSM, and shape modes were associated with RV and LV size, and diagnosis. BIV repair was achieved in 74 (78%) patients; and 13 (18%) of BIV patients had MACE. Predictors of MACE following BIV repair included EFE, higher RV mass index, and higher RV end-diastolic volume index. No baseline or post-recruitment LV shape parameter was associated with outcome after BIV repair.
Conclusions: The shape model of hypoplastic LVs demonstrated a wide array of LV shapes. LVs gained sphericity and size and lost eccentricity with recruitment. Though the ventricles changed shape with recruitment, no specific LV shape characteristic at the baseline or post-recruitment stage was predictive of decision to proceed with BIV repair nor outcome. Higher RV mass and volume may represent new biomarkers that predict outcome following BIV repair in patients with hypoplastic LV. Further investigation could determine the reproducibility of these findings.
期刊介绍：
Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to:
New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system.
New methods to enhance or accelerate image acquisition and data analysis.
Results of multicenter, or larger single-center studies that provide insight into the utility of CMR.
Basic biological perceptions derived by CMR methods.
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