Parental Smoking and the Risk of Birth Defects in Offspring in China: A Systematic Review and meta-Analysis

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2024-12-08 DOI:10.1002/bdr2.2422

Jinxi Han, Yunxia Zhang, Yibo Liu, Jikai Liu, Yuehua Zhang, Kaijuan Wang

{"title":"Parental Smoking and the Risk of Birth Defects in Offspring in China: A Systematic Review and meta-Analysis","authors":"Jinxi Han, Yunxia Zhang, Yibo Liu, Jikai Liu, Yuehua Zhang, Kaijuan Wang","doi":"10.1002/bdr2.2422","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>A meta-analysis of case-control studies was conducted to assess the risk of birth defects in offspring in China associated with maternal active and passive smoking and paternal smoking.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Four electronic databases were searched for qualified research up to December 2023. A Random-effect model or fixed-effect model was used to calculate the overall comprehensive risk estimates; and the relationship between parental smoking and the risk of birth defects in different periods of pregnancy. Subgroup and sensitivity analyses were performed to explore possible sources of heterogeneity.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Sixty-two qualified studies involving 137,574 cases and 8,770,837 controls were included. Overall, maternal active smoking (OR = 2.19; 95% confidence interval (CI): 1.72–2.79; <i>p</i> < 0.01) and passive smoking (OR = 2.59,95% CI: 2.24–2.99; <i>p</i> < 0.01) as well as paternal active smoking (OR = 1.47,95% CI: 1.34–1.62; <i>p</i> < 0.01) were significantly associated with birth defect risk. The sources of heterogeneity were explored by subgroup analysis. Subgroup analysis showed that the risk of congenital heart disease in offspring was increased in paternal and maternal active smoking (OR = 2.97, 95% CI: 2.01–4.39; OR = 1.51, 95% CI: 1.30–1.74), respectively. Sensitivity analysis yielded consistent results.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Maternal active and passive smoking and paternal active smoking are risk factors for birth defects in offspring. Parents should be encouraged to quit smoking during the perinatal period and pregnancy.</p>\n </section>\n </div>","PeriodicalId":9121,"journal":{"name":"Birth Defects Research","volume":"116 12","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Birth Defects Research","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2422","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

A meta-analysis of case-control studies was conducted to assess the risk of birth defects in offspring in China associated with maternal active and passive smoking and paternal smoking.

Methods

Four electronic databases were searched for qualified research up to December 2023. A Random-effect model or fixed-effect model was used to calculate the overall comprehensive risk estimates; and the relationship between parental smoking and the risk of birth defects in different periods of pregnancy. Subgroup and sensitivity analyses were performed to explore possible sources of heterogeneity.

Results

Sixty-two qualified studies involving 137,574 cases and 8,770,837 controls were included. Overall, maternal active smoking (OR = 2.19; 95% confidence interval (CI): 1.72–2.79; p < 0.01) and passive smoking (OR = 2.59,95% CI: 2.24–2.99; p < 0.01) as well as paternal active smoking (OR = 1.47,95% CI: 1.34–1.62; p < 0.01) were significantly associated with birth defect risk. The sources of heterogeneity were explored by subgroup analysis. Subgroup analysis showed that the risk of congenital heart disease in offspring was increased in paternal and maternal active smoking (OR = 2.97, 95% CI: 2.01–4.39; OR = 1.51, 95% CI: 1.30–1.74), respectively. Sensitivity analysis yielded consistent results.

Conclusion

Maternal active and passive smoking and paternal active smoking are risk factors for birth defects in offspring. Parents should be encouraged to quit smoking during the perinatal period and pregnancy.

查看原文本刊更多论文

中国父母吸烟与后代出生缺陷风险：系统回顾和荟萃分析。

目的：对病例对照研究进行荟萃分析，以评估中国母亲主动和被动吸烟以及父亲吸烟与后代出生缺陷的风险关系。方法：检索截至2023年12月的4个电子数据库。采用随机效应模型或固定效应模型计算总体综合风险估计值；以及父母吸烟与不同孕期出生缺陷风险之间的关系。进行亚组分析和敏感性分析以探索可能的异质性来源。结果：纳入62项合格研究，涉及137,574例病例和8,770,837例对照。总体而言，产妇主动吸烟(OR = 2.19；95%置信区间（CI）： 1.72 ~ 2.79；结论：母亲主动、被动吸烟和父亲主动吸烟是子代出生缺陷的危险因素。应鼓励父母在围产期和怀孕期间戒烟。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.