Scott E. Kasner MD, Michael T. Mullen MD, Michael DeGeorgia MD, Spiros Blackburn MD, Donna K. George MD, Monisha Kumar MD, Steven Messe MD, Michael G. Abraham MD, Michael Chen MD, Santiago Ortega-Gutierrez MD, Clark W. Sitton MD, Jan-Karl Burkhardt MD, Muhammad Shazam Hussain MD, Leonid Churilov PhD, Sophia Sundararajan MD, Yin C. Hu MD, Nabeel A. Herial MD, Pascal Jabbour MD, Daniel Gibson MD, Juan F. Arenillas MD, PhD, Jenny P. Tsai MD, Ronald F. Budzik MD, William J. Hicks MD, Osman Kozak MD, Bernard Yan MBBS, Dennis J. Cordato PhD, Nathan W. Manning MBBS, Mark W. Parsons PhD, Ricardo A. Hanel MD, Amin N. Aghaebrahim MD, Teddy Y. Wu PhD, Pere Cardona Portela MD, Natalia Pérez de la Ossa MD, PhD, Joanna D. Schaafsma MD, Jordi Blasco MD, PhD, Navdeep Sangha MD, Steven Warach MD, Chirag D. Gandhi MD, Timothy J. Kleinig PhD, Daniel Sahlein MD, Edgar A. Samaniego MD, Laith Maali MD, Mohammad A. Abdulrazzak MD, Krishna Amuluru MD, Deep K. Pujara MBBS, Faris Shaker MBChB, Hannah Johns PhD, Rami Moussa BS, Faisal Al-Shaibi MD, Kelsey R. Duncan MD, Stavropoula Tjoumakaris MD, Amanda Opaskar MD, Wei Xiong MD, Abhishek Ray MD, Sepideh Amin-Hanjani MD, Thanh N. Nguyen MD, Johanna T. Fifi MD, Stephen Davis MD, Lawrence Wechsler MD, Anthony Furlan MD, Cathy Sila MD, Nicholas Bambakidis MD, Michael D. Hill MD, Vitor Mendes Pereira MD, Maarten G. Lansberg MD, James C. Grotta MD, Marc Ribo MD, Greg W. Albers MD, Bruce C. Campbell PhD, Ameer E. Hassan DO, Amrou Sarraj MD, for the SELECT2 Investigators
{"title":"Critical Care Decisions After Large Core Cerebral Infarctions: A Secondary Analysis From the SELECT2 Trial","authors":"Scott E. Kasner MD, Michael T. Mullen MD, Michael DeGeorgia MD, Spiros Blackburn MD, Donna K. George MD, Monisha Kumar MD, Steven Messe MD, Michael G. Abraham MD, Michael Chen MD, Santiago Ortega-Gutierrez MD, Clark W. Sitton MD, Jan-Karl Burkhardt MD, Muhammad Shazam Hussain MD, Leonid Churilov PhD, Sophia Sundararajan MD, Yin C. Hu MD, Nabeel A. Herial MD, Pascal Jabbour MD, Daniel Gibson MD, Juan F. Arenillas MD, PhD, Jenny P. Tsai MD, Ronald F. Budzik MD, William J. Hicks MD, Osman Kozak MD, Bernard Yan MBBS, Dennis J. Cordato PhD, Nathan W. Manning MBBS, Mark W. Parsons PhD, Ricardo A. Hanel MD, Amin N. Aghaebrahim MD, Teddy Y. Wu PhD, Pere Cardona Portela MD, Natalia Pérez de la Ossa MD, PhD, Joanna D. Schaafsma MD, Jordi Blasco MD, PhD, Navdeep Sangha MD, Steven Warach MD, Chirag D. Gandhi MD, Timothy J. Kleinig PhD, Daniel Sahlein MD, Edgar A. Samaniego MD, Laith Maali MD, Mohammad A. Abdulrazzak MD, Krishna Amuluru MD, Deep K. Pujara MBBS, Faris Shaker MBChB, Hannah Johns PhD, Rami Moussa BS, Faisal Al-Shaibi MD, Kelsey R. Duncan MD, Stavropoula Tjoumakaris MD, Amanda Opaskar MD, Wei Xiong MD, Abhishek Ray MD, Sepideh Amin-Hanjani MD, Thanh N. Nguyen MD, Johanna T. Fifi MD, Stephen Davis MD, Lawrence Wechsler MD, Anthony Furlan MD, Cathy Sila MD, Nicholas Bambakidis MD, Michael D. Hill MD, Vitor Mendes Pereira MD, Maarten G. Lansberg MD, James C. Grotta MD, Marc Ribo MD, Greg W. Albers MD, Bruce C. Campbell PhD, Ameer E. Hassan DO, Amrou Sarraj MD, for the SELECT2 Investigators","doi":"10.1002/ana.27151","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>Among patients with large vessel occlusion (LVO) and large ischemic cores, critical decisions often need to be made about decompressive hemicraniectomy (DHC) or early withdrawal of life-sustaining therapy (WLST). In this study, we aimed to evaluate utilization of DHC and early WLST and factors associated with them in patients with large strokes from the SELECT2 trial.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We analyzed the entire SELECT2 trial population, which randomized 352 patients with stroke due to LVO and large ischemic cores to endovascular thrombectomy (EVT) or medical management. We used the as-treated principle to compare the use of DHC and early WLST within 7 days after randomization. We further assessed functional outcomes (modified Rankin Score) after these decisions.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Of 352 patients enrolled in this study, 55 received DHC and 81 transitioned to early WLST. Patients treated with EVT were as likely to undergo DHC (16% vs 15%, adjusted relative risk [aRR] = 1.19, 95% CI:0.75–1.88, <i>p</i> = 0.46) or WLST (22% vs 24%, aRR = 0.94, 95% CI: 0.66–1.34, <i>p</i> = 0.72) as those given medical management. DHC was used more frequently in younger patients and WLST more in older patients. EVT efficacy was maintained after adjusting for DHC (adjusted generalized odds ratio [aGenOR] = 1.68, 95% CI: 1.24–2.11, <i>p</i> < 0.001), with no interaction between DHC and treatment (p-interaction = 0.93). At 1 year, 21% of DHC-treated patients were ambulatory; the outcomes were universally poor after early WLST.</p>\n </section>\n \n <section>\n \n <h3> Interpretation</h3>\n \n <p>In the SELECT2 trial of patients with large ischemic core, DHC was performed in ~1 of 6 patients and early WLST in ~1 of 5 patients, without differences based on treatment with EVT or medical management, nor successful reperfusion. DHC or WLST did not detract from thrombectomy treatment benefit. Additionally, ~20% of patients achieved independent ambulation despite receiving DHC by the 1-year follow-up. The similar distribution of these critical care decisions provides reassurance that the overall trial outcomes were not biased by open-label treatment allocation. ANN NEUROL 2025;97:698–708</p>\n </section>\n </div>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":"97 4","pages":"698-708"},"PeriodicalIF":8.1000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Neurology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ana.27151","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective
Among patients with large vessel occlusion (LVO) and large ischemic cores, critical decisions often need to be made about decompressive hemicraniectomy (DHC) or early withdrawal of life-sustaining therapy (WLST). In this study, we aimed to evaluate utilization of DHC and early WLST and factors associated with them in patients with large strokes from the SELECT2 trial.
Methods
We analyzed the entire SELECT2 trial population, which randomized 352 patients with stroke due to LVO and large ischemic cores to endovascular thrombectomy (EVT) or medical management. We used the as-treated principle to compare the use of DHC and early WLST within 7 days after randomization. We further assessed functional outcomes (modified Rankin Score) after these decisions.
Results
Of 352 patients enrolled in this study, 55 received DHC and 81 transitioned to early WLST. Patients treated with EVT were as likely to undergo DHC (16% vs 15%, adjusted relative risk [aRR] = 1.19, 95% CI:0.75–1.88, p = 0.46) or WLST (22% vs 24%, aRR = 0.94, 95% CI: 0.66–1.34, p = 0.72) as those given medical management. DHC was used more frequently in younger patients and WLST more in older patients. EVT efficacy was maintained after adjusting for DHC (adjusted generalized odds ratio [aGenOR] = 1.68, 95% CI: 1.24–2.11, p < 0.001), with no interaction between DHC and treatment (p-interaction = 0.93). At 1 year, 21% of DHC-treated patients were ambulatory; the outcomes were universally poor after early WLST.
Interpretation
In the SELECT2 trial of patients with large ischemic core, DHC was performed in ~1 of 6 patients and early WLST in ~1 of 5 patients, without differences based on treatment with EVT or medical management, nor successful reperfusion. DHC or WLST did not detract from thrombectomy treatment benefit. Additionally, ~20% of patients achieved independent ambulation despite receiving DHC by the 1-year follow-up. The similar distribution of these critical care decisions provides reassurance that the overall trial outcomes were not biased by open-label treatment allocation. ANN NEUROL 2025;97:698–708
期刊介绍:
Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.