Fracture Behavior and Biocompatibility of Cellulose Nanofiber-Reinforced Poly(vinyl alcohol) Composite Hydrogels Cross-Linked with Borax.

IF 5.5 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-08 DOI:10.1021/acs.biomac.4c01199

Takumi Narita, Wen-Chuan Hsieh, Yu Tzu Ku, Yu-Chieh Su, Hiroki Inoguchi, Hiroyuki Takeno

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引用次数: 0

Abstract

We investigated the fracture behavior of cellulose nanofiber (CNF)-reinforced poly(vinyl alcohol) (PVA) hydrogels cross-linked with borax and the effect of freeze-thaw (FT) cycles on it. The CNF/PVA/Borax hydrogel not subjected to FT achieved a fracture energy of 5.8 kJ m^-2 and a dissipative length of 2.3 mm, comparable to those of tough hydrogels. Lacking either CNF or borax remarkably decreased the fracture energy and the dissipative length; CNF contributed to a physical blocking of the crack growth, whereas the complexations between CNF and borate yielded nonlocalization of energy dissipation. Repeated FT cycles markedly improved the mechanical performance of unnotched samples, but they decreased the fracture energy due to the lowering of the dissipative length. Besides, CNF/PVA/Borax hydrogels were suitable for cell scaffold materials. The culture of umbilical cord mesenchymal stem cells (UC-MSCs) revealed a positive correlation between culture duration and the number of UC- MSCs adherent to the material.

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硼砂交联纤维素纳米纤维增强聚乙烯醇复合水凝胶的断裂行为和生物相容性。

研究了硼砂交联纤维素纳米纤维（CNF）增强聚乙烯醇（PVA）水凝胶的断裂行为以及冻融循环对其断裂行为的影响。未经FT处理的CNF/PVA/硼砂水凝胶的断裂能为5.8 kJ - m-2，耗散长度为2.3 mm，与韧性水凝胶相当。缺少CNF或硼砂均显著降低了断裂能和耗散长度；CNF有助于物理阻塞裂纹扩展，而CNF与硼酸盐之间的络合产生非局部化的能量耗散。重复的FT循环明显改善了无缺口样品的力学性能，但由于耗散长度的降低，它们降低了断裂能。此外，CNF/PVA/硼砂水凝胶适合作为细胞支架材料。脐带间充质干细胞（UC-MSCs）的培养结果表明，培养时间与粘附在材料上的UC-MSCs数量呈正相关。

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.