Not only the top: Type I topoisomerases function in multiple tissues and organs development in plants

IF 11.4 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of Advanced Research Pub Date : 2024-12-09 DOI:10.1016/j.jare.2024.12.011

Hao Zhang, Lirong Tian, Yuru Ma, Jiahui Xu, Tianyu Bai, Qian Wang, Xigang Liu, Lin Guo

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引用次数: 0

Abstract

Background

DNA topoisomerases (TOPs) are essential components in a diverse range of biological processes including DNA replication, transcription and genome integrity. Although the functions and mechanisms of TOPs, particularly type I TOP (TOP1s), have been extensively studied in bacteria, yeast and animals, researches on these proteins in plants have only recently commenced.

Aim of Review

In this review, the function and mechanism studies of TOP1s in plants and the structural biology of plant TOP1 are presented, providing readers with a comprehensive understanding of the current research status of this essential enzyme.The future research directions for exploring the working mechanism of plant TOP1s is also discussed.

Key Scientific Concepts of Review

Over the past decade, it has been discovered TOP1s play a vital role in multiphasic processes of plant development, such as maintaining meristem activity, gametogenesis, flowering time, gravitropic response and so on. Plant TOP1s affects gene transcription by modulating chromatin status, including chromatin accessibility, DNA/RNA structure, and nucleosome positioning. However, the function and mechanism of this vital enzyme is poorly summarized although it has been systematically summarized in other species. This review summarized the research progresses of plant TOP1s according to the diverse functions and working mechanism in different tissues.

Abstract Image

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不只是顶部：I型拓扑异构酶在植物的多个组织和器官发育中起作用

DNA拓扑异构酶（topoisomerase, TOPs）是多种生物过程（包括DNA复制、转录和基因组完整性）的重要组成部分。尽管在细菌、酵母和动物中对TOP的功能和机制，特别是I型TOP （top1）的功能和机制已经进行了广泛的研究，但对这些蛋白质在植物中的研究只是最近才开始。本文综述了TOP1在植物中的功能和作用机制以及植物TOP1的结构生物学研究，使读者对这一重要酶的研究现状有一个全面的了解。展望了植物top1工作机制的未来研究方向。近十年来，人们发现top1在植物发育的多相过程中起着至关重要的作用，如维持分生组织活性、配子体发生、开花时间、向地性反应等。植物top1通过调节染色质状态影响基因转录，包括染色质可及性、DNA/RNA结构和核小体定位。然而，尽管在其他物种中对这种重要酶的功能和机制进行了系统的总结，但对其功能和机制的总结却很少。本文就植物top1在不同组织中的不同功能和作用机制的研究进展进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Advanced Research Multidisciplinary-Multidisciplinary

CiteScore

21.60

自引率

0.90%

发文量

280

审稿时长

12 weeks

期刊介绍： Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.