Do obstructive and restrictive pulmonary disorders increase the incidence risk of dynapenia in adults aged 50 and older?

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2024-11-22 DOI:10.1016/j.archger.2024.105701

Thales Batista de Souza , Roberta de Oliveira Máximo , Isabella Letícia de Pádua Cruz e Souza , Thaís Barros Pereira da Silva , Mariane Marques Luiz , Sara Souza Lima , Natália Cochar-Soares , Leticia Coelho Silveira , Valdete Regina Guandalini , Patrícia Silva Tofani , Andrew Steptoe , Cesar de Oliveira , Tiago da Silva Alexandre

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引用次数: 0

Abstract

Objective

This study aims to evaluate whether obstructive or restrictive lung disorders are associated with the incidence of dynapenia in individuals aged 50 and over.

Methods

Longitudinal study involving 4,975 participants from the English Longitudinal Study of Aging (ELSA) aged 50 or older, without dynapenia at baseline, followed for eight years. Lung function was assessed by spirometry (predicted percentage) and participants were classified as no pulmonary disorder (FEV₁ ≥ 80 %, FVC ≥ 80 % and FEV₁/FVC ≥ 70 %); with obstructive pulmonary disorder (FEV₁ < 80 %, FEV₁/FVC < 70 % and normal FVC or < 80 %); or with restrictive pulmonary disorder (FVC < 80 %, FEV₁/FVC > 70 % and normal or < 80 % FEV₁). The incidence of dynapenia was defined by handgrip strength < 26 kg for men and < 16 kg for women. Association between obstructive or restrictive pulmonary disorders and the incidence of dynapenia were investigated using Poisson regression models adjusted for sociodemographic, behavioural, and clinical characteristics.

Results

The incidence density of dynapenia was 14.2/1000 person-years (95 %CI 12.6–15.9) in those without pulmonary disorders, 25.1/1000 person-years (95 % CI 21.2–29.7) in those with restrictive pulmonary disorders and 36.6/1000 person-years (95 % CI 23.8–56.1) in those with obstructive pulmonary disorders. Having an obstructive pulmonary disorder increased the risk of developing dynapenia by 62 % (95 % CI 1.09–2.41), while having a restrictive pulmonary disorder increased the risk by 37 % (95 % CI 1.13–1.64).

Conclusion

Obstructive and restrictive pulmonary disorders are risk factors for a higher incidence of dynapenia in individuals aged 50 years or older.

查看原文本刊更多论文

阻塞性和限制性肺疾病是否会增加50岁及以上成年人发生运动障碍的风险？

目的：本研究旨在评估50岁及以上人群中阻塞性或限制性肺疾病是否与运动障碍发生率相关。方法：纵向研究涉及4,975名参与者，他们来自英国老龄化纵向研究（ELSA），年龄在50岁或以上，基线时无运动障碍，随访8年。通过肺活量测定法（预测百分比）评估肺功能，并将参与者分类为无肺部疾病（FEV1≥80%，FVC≥80%和FEV1/FVC≥70%）；阻塞性肺疾病（FEV1 < 80%, FEV1/FVC < 70%， FVC正常或< 80%）；或伴有限制性肺疾病（FVC < 80%, FEV1/FVC > 70%， FEV1正常或< 80%）。男性握力< 26公斤、女性< 16公斤定义为动力不足的发生率。使用泊松回归模型对社会人口学、行为和临床特征进行调整，研究阻塞性或限制性肺疾病与运动障碍发生率之间的关系。结果：无肺疾病患者的运动障碍发生率密度为14.2/1000人年（95% CI 12.6-15.9），限制性肺疾病患者为25.1/1000人年（95% CI 21.2-29.7），阻塞性肺疾病患者为36.6/1000人年（95% CI 23.8-56.1）。患有阻塞性肺疾病的患者发生动力障碍的风险增加62% (95% CI 1.09-2.41)，而患有限制性肺疾病的患者发生动力障碍的风险增加37% （95% CI 1.13-1.64）。结论：阻塞性和限制性肺疾病是50岁及以上人群运动障碍发生率较高的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.