Severe hypertransaminasaemia during the acute hepatitis of unknown origin alert of 2022

Ana Martín Costa , Ignacio Ros Arnal , Ruth García Romero , Gerardo Rodríguez Martínez , Beatriz García Rodríguez
{"title":"Severe hypertransaminasaemia during the acute hepatitis of unknown origin alert of 2022","authors":"Ana Martín Costa ,&nbsp;Ignacio Ros Arnal ,&nbsp;Ruth García Romero ,&nbsp;Gerardo Rodríguez Martínez ,&nbsp;Beatriz García Rodríguez","doi":"10.1016/j.anpede.2024.11.007","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>The impact of acute severe hepatitis of unknown origin in children (SHIC) subject to a medical alert in 2022 medical alert is poorly understood.</div></div><div><h3>Materials and methods</h3><div>Observational study of the incidence, aetiology and clinical presentation of acute hypertransaminasaemia (HTRA) with laboratory values in the severe range (ALT and/or AST ≥ 500 U/L) in paediatric patients (age 0 to 16 years) in one health care zone from 2012 to 2022, comparing the periods of the SHIC alert and the SARS-CoV2 pandemic with previous years.</div></div><div><h3>Results</h3><div>The incidence of severe HTRA of any cause was 195.28 per 100 000 blood tests, with an incidence of 181.38 in the SHIC alert period and 166.09 during the SARS-CoV-2 pandemic, without statistically significant differences.</div><div>Hepatitis of unknown origin accounted for 7.42% of total cases and transaminase levels normalised in 126 days (SD, 99.4). During the SHIC alert period there was a nonsignificant trend towards a higher incidence, as occurred in 2012 and 2018. In this group of cases, there was a significant increase in the presence of fever, vomiting and upper respiratory symptoms and lower levels of albumin and alkaline phosphatase. One patient required a liver transplant.</div></div><div><h3>Conclusions</h3><div>In our setting, there was no significant increase in the incidence of severe HTRA of any aetiology or of unknown source during either the SHIC alert or the SARS-CoV2 pandemic. In the SHIC alert period, a clinical pattern emerged characterised by an increase in nonspecific infectious symptoms, so we cannot rule out a higher prevalence of an infectious agent different from the usual involved pathogens, but it did not cause a significant change in epidemiological trends.</div></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"101 6","pages":"Pages 370-377"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anales de pediatria","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2341287924002850","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction

The impact of acute severe hepatitis of unknown origin in children (SHIC) subject to a medical alert in 2022 medical alert is poorly understood.

Materials and methods

Observational study of the incidence, aetiology and clinical presentation of acute hypertransaminasaemia (HTRA) with laboratory values in the severe range (ALT and/or AST ≥ 500 U/L) in paediatric patients (age 0 to 16 years) in one health care zone from 2012 to 2022, comparing the periods of the SHIC alert and the SARS-CoV2 pandemic with previous years.

Results

The incidence of severe HTRA of any cause was 195.28 per 100 000 blood tests, with an incidence of 181.38 in the SHIC alert period and 166.09 during the SARS-CoV-2 pandemic, without statistically significant differences.
Hepatitis of unknown origin accounted for 7.42% of total cases and transaminase levels normalised in 126 days (SD, 99.4). During the SHIC alert period there was a nonsignificant trend towards a higher incidence, as occurred in 2012 and 2018. In this group of cases, there was a significant increase in the presence of fever, vomiting and upper respiratory symptoms and lower levels of albumin and alkaline phosphatase. One patient required a liver transplant.

Conclusions

In our setting, there was no significant increase in the incidence of severe HTRA of any aetiology or of unknown source during either the SHIC alert or the SARS-CoV2 pandemic. In the SHIC alert period, a clinical pattern emerged characterised by an increase in nonspecific infectious symptoms, so we cannot rule out a higher prevalence of an infectious agent different from the usual involved pathogens, but it did not cause a significant change in epidemiological trends.

Abstract Image

2022年不明原因急性肝炎预警期间的严重高转氨酶血症。
在2022年医疗警报中,儿童不明原因急性重型肝炎(SHIC)受到医疗警报的影响尚不清楚。材料与方法:对2012 - 2022年某卫生保健区0 ~ 16岁儿童急性高转氨酶血症(HTRA)实验室值在严重范围(ALT和/或AST ≥ 500 U/L)的发生率、病因学和临床表现进行观察性研究,并将SHIC预警和SARS-CoV2大流行期间与以往进行比较。结果:各原因严重HTRA发生率为195.28 / 10万,其中SHIC警戒期为181.38 / 10万,SARS-CoV-2大流行期为166.09 / 10万,差异无统计学意义。原因不明的肝炎占总病例的7.42%,转氨酶水平在126天内恢复正常(SD, 99.4)。在SHIC警报期间,与2012年和2018年一样,发病率呈不显著的上升趋势。在这组病例中,发热、呕吐和上呼吸道症状明显增加,白蛋白和碱性磷酸酶水平降低。一名患者需要肝脏移植。结论:在我们的环境中,在SHIC警报或SARS-CoV2大流行期间,任何病因或不明来源的严重HTRA发生率均未显着增加。在SHIC警戒期,出现了以非特异性感染症状增加为特征的临床模式,因此我们不能排除与通常涉及的病原体不同的感染因子的较高流行率,但它没有引起流行病学趋势的显着变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
审稿时长
20 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信