Current advancements in fungal engineering technologies for Sustainable Development Goals.

IF 14 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Microbiology Pub Date : 2024-12-06 DOI:10.1016/j.tim.2024.11.001

Shilpa Garg, Minji Kim, David Romero-Suarez

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Abstract

Fungi are emerging as key organisms in tackling global challenges related to agricultural and food productivity, environmental sustainability, and climate change. This review delves into the transformative potential of fungal genomics and metabolic engineering, two forefront fields in modern biotechnology. Fungal genomics entails the thorough analysis and manipulation of fungal genetic material to enhance desirable traits, such as pest resistance, nutrient absorption, and stress tolerance. Metabolic engineering focuses on altering the biochemical pathways within fungi to optimize the production of valuable compounds, including biofuels, pharmaceuticals, and industrial enzymes. By artificial intelligence (AI)-driven integration of genetic and metabolic engineering techniques, we can harness the unique capabilities of both filamentous and mycorrhizal fungi to develop sustainable agricultural practices, enhance soil health, and promote ecosystem restoration. This review explores the current state of research, technological advancements, and practical applications, offering insights into scalability challenges on how integrative fungal genomics and metabolic engineering can deliver innovative solutions for a sustainable future.

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可持续发展目标中真菌工程技术的最新进展。

真菌正在成为解决与农业和粮食生产力、环境可持续性和气候变化有关的全球挑战的关键生物。本文综述了真菌基因组学和代谢工程这两个现代生物技术的前沿领域的变革潜力。真菌基因组学需要对真菌遗传物质进行彻底的分析和操作，以增强理想的性状，如抗虫害、营养吸收和耐受性。代谢工程专注于改变真菌内部的生化途径，以优化有价值化合物的生产，包括生物燃料、药物和工业酶。通过人工智能（AI）驱动的遗传和代谢工程技术的整合，我们可以利用丝状真菌和菌根真菌的独特能力来开发可持续农业实践，增强土壤健康，促进生态系统恢复。这篇综述探讨了真菌基因组学的研究现状、技术进步和实际应用，提供了关于真菌基因组学和代谢工程如何为可持续未来提供创新解决方案的可扩展性挑战的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Microbiology 生物-生化与分子生物学

CiteScore

25.30

自引率

0.60%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.