Leptin Levels in Acute and Recovered Eating Disorders: An Arm-Based Network Meta-Analysis.

IF 3.9 2区心理学 Q1 PSYCHIATRY

European Eating Disorders Review Pub Date : 2024-12-06 DOI:10.1002/erv.3163

Emanuele Cassioli, Lorenzo Lucherini Angeletti, Eleonora Rossi, Giulia Selvi, Elena Riccardi, Serena Siviglia, Roberta Buonanno, Valdo Ricca, Giovanni Castellini

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引用次数: 0

Abstract

Objective: This study aimed to provide a BMI-adjusted meta-analytical calculation of blood leptin levels across different eating disorders (EDs) including anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED), recovered EDs, and healthy controls (HCs). The goal was to understand BMI-independent leptin alterations and their potential as biomarkers.

Method: PubMed and ClinicalTrials.gov were searched for studies reporting serum leptin in AN, BN, BED, or recovered EDs. A multilevel network meta-analysis using a linear mixed-effects meta-regression model, adjusting for BMI, sex, and assay type, was performed on 146 studies (5048 patients, 3525 controls).

Results: Significant differences in leptin levels were found across EDs. AN patients exhibited the lowest leptin levels, while BED patients had the highest. BN and recovered AN patients had leptin levels similar to AN, significantly lower than HCs. BMI, sex, and assay type were significant covariates. The model accounted for heterogeneity due to diagnostic criteria, assay types, and study-level differences.

Conclusions: Leptin levels in EDs are significantly altered beyond BMI effects, suggesting disease-specific factors. These findings support leptin's potential as a biomarker for ED staging and prognosis. Further research is needed to explore leptin's role in ED pathogenesis and trajectory, to identify subpopulations and improve clinical interventions.

查看原文本刊更多论文

急性和恢复饮食失调的瘦素水平：一项基于手臂的网络meta分析。

目的：本研究旨在对不同饮食失调（包括神经性厌食症（AN）、神经性贪食症（BN）、暴食症（BED）、恢复的饮食失调和健康对照（hc））患者的血瘦素水平进行bmi调整后的meta分析计算。目的是了解与bmi无关的瘦素变化及其作为生物标志物的潜力。方法：检索PubMed和ClinicalTrials.gov网站上报道AN、BN、BED或恢复ed患者血清瘦素的研究。采用线性混合效应元回归模型，对146项研究（5048例患者，3525例对照）进行了多层网络荟萃分析，调整了BMI、性别和试验类型。结果：不同ed患者瘦素水平有显著差异。AN患者瘦素水平最低，而BED患者瘦素水平最高。BN和恢复的AN患者瘦素水平与AN相似，明显低于hc。BMI、性别和试验类型是显著的协变量。该模型解释了由于诊断标准、检测类型和研究水平差异而产生的异质性。结论：ed患者瘦素水平的显著改变超出了BMI的影响，提示疾病特异性因素。这些发现支持瘦素作为ED分期和预后的生物标志物的潜力。需要进一步研究瘦素在ED发病机制和轨迹中的作用，以确定亚群并改进临床干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Eating Disorders Review PSYCHOLOGY, CLINICAL-

CiteScore

8.90

自引率

7.50%

发文量

期刊介绍： European Eating Disorders Review publishes authoritative and accessible articles, from all over the world, which review or report original research that has implications for the treatment and care of people with eating disorders, and articles which report innovations and experience in the clinical management of eating disorders. The journal focuses on implications for best practice in diagnosis and treatment. The journal also provides a forum for discussion of the causes and prevention of eating disorders, and related health policy. The aims of the journal are to offer a channel of communication between researchers, practitioners, administrators and policymakers who need to report and understand developments in the field of eating disorders.