Emerging strategies targeting genes and cells in glaucoma.

IF 1.5 4区 心理学 Q4 NEUROSCIENCES
Suva Roy
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引用次数: 0

Abstract

Glaucoma comprises a heterogeneous set of eye conditions that cause progressive vision loss. Glaucoma has a complex etiology, with different genetic and non-genetic risk factors that differ across populations. Although difficult to diagnose in early stages, compromised cellular signaling, dysregulation of genes, and homeostatic imbalance are common precursors to injury and subsequent death of retinal ganglion cells (RGCs). Lowering intraocular pressure (IOP) remains the primary approach for managing glaucoma but IOP alone does not explain all glaucoma risks. Orthogonal approaches such as large-scale genetic screening, combined with studies of animal models have been instrumental in identifying genes and molecular pathways involved in glaucoma pathogenesis. Cell type dependent vulnerability among RGCs can reveal genetic basis for specific visual deficits. A growing body of knowledge and availability of modern tools to perform targeted assessments of cellular health in different animal models facilitate development of effective and timely interventions for vision rescue. This review highlights recent findings on genes, molecules, and cell types in the context of glaucoma pathophysiology and treatment.

针对青光眼基因和细胞的新策略。
青光眼包括一组引起进行性视力丧失的异质眼病。青光眼的病因复杂,不同人群的遗传和非遗传风险因素不同。虽然在早期阶段难以诊断,但细胞信号受损、基因失调和体内平衡失衡是视网膜神经节细胞(RGCs)损伤和随后死亡的常见前驱。降低眼内压(IOP)仍然是治疗青光眼的主要方法,但仅IOP并不能解释所有青光眼的风险。正交法,如大规模遗传筛选,结合动物模型研究,有助于确定参与青光眼发病机制的基因和分子途径。RGCs中细胞类型依赖性易感性可以揭示特异性视觉缺陷的遗传基础。在不同动物模型中对细胞健康进行有针对性评估的知识体系和现代工具的可用性不断增加,有助于开发有效和及时的视力拯救干预措施。本文综述了在青光眼病理生理和治疗方面的基因、分子和细胞类型的最新发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Vision Research
Vision Research 医学-神经科学
CiteScore
3.70
自引率
16.70%
发文量
111
审稿时长
66 days
期刊介绍: Vision Research is a journal devoted to the functional aspects of human, vertebrate and invertebrate vision and publishes experimental and observational studies, reviews, and theoretical and computational analyses. Vision Research also publishes clinical studies relevant to normal visual function and basic research relevant to visual dysfunction or its clinical investigation. Functional aspects of vision is interpreted broadly, ranging from molecular and cellular function to perception and behavior. Detailed descriptions are encouraged but enough introductory background should be included for non-specialists. Theoretical and computational papers should give a sense of order to the facts or point to new verifiable observations. Papers dealing with questions in the history of vision science should stress the development of ideas in the field.
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