PTEN regulation in virus-associated cancers

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2025-02-01 DOI:10.1016/j.prp.2024.155749

Shaian Tavakolian , Zahra Shokati Eshkiki , Abolfazl Akbari , Ebrahim Faghihloo , Seidamir Pasha Tabaeian

引用次数: 0

Abstract

Despite advancements in science, researchers still face challenges in curing patients with malignancies. This health issue is linked to various risk factors, including alcohol consumption, age, sex, and infectious diseases. Among these, viral agents play a significant role in cancer-related health problems and are currently a subject of ongoing research. In this review, we summarize how several viruses—such as herpesviruses, human papillomavirus, hepatitis B virus, hepatitis C virus, and adenovirus—impact cancer signaling pathways through their effects on the tumor suppressor PTEN.

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PTEN在病毒相关癌症中的调控

尽管科学取得了进步，但研究人员在治疗恶性肿瘤患者方面仍然面临挑战。这一健康问题与各种风险因素有关，包括饮酒、年龄、性别和传染病。其中，病毒因子在癌症相关的健康问题中起着重要作用，目前是一个正在进行的研究课题。在这篇综述中，我们总结了几种病毒，如疱疹病毒、人乳头瘤病毒、乙型肝炎病毒、丙型肝炎病毒和腺病毒是如何通过它们对肿瘤抑制因子PTEN的作用来影响癌症信号通路的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.