Vanadium exposure and kidney markers in a pediatric population: a cross-sectional study.

IF 2.6 3区医学 Q1 PEDIATRICS

Pediatric Nephrology Pub Date : 2025-05-01 Epub Date: 2024-12-07 DOI:10.1007/s00467-024-06561-9

Elodia Rojas-Lima, Manolo Ortega-Romero, Octavio Gamaliel Aztatzi-Aguilar, Juan Carlos Rubio-Gutiérrez, Juana Narváez-Morales, Mariela Esparza-García, Pablo Méndez-Hernández, Mara Medeiros, Olivier Christophe Barbier

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引用次数: 0

Abstract

Background: Anthropogenic vanadium (V) emissions and exposure in the general population have recently increased. Experimental studies have shown that V is a nephrotoxic agent, but little is known about its effects on human kidney health. This work evaluated the association between urinary V concentrations with early kidney damage biomarkers and function in a pediatric population without any disease diagnosed.

Methods: A cross-sectional study was carried out and included 914 healthy subjects and determined urinary V concentrations, glomerular filtration rate (eGFR), albumin-creatinine ratio (ACR), and the presence of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in urine. We evaluated the V effect using linear and logistic regression models adjusted by confounders.

Results: Subjects found in the second and third tertiles of V showed an increase in urinary log-NGAL levels (βT2 vs. T1 = 0.39; 95% CI 0.14, 0.64, and βT3 vs. T1 = 1.04; 95% CI 0.75, 1.34) and log-KIM-1(βT2 vs. T1 = 0.25; 95% CI 0.04, 0.45 and βT3 vs. T1 = 0.39; 95% CI 0.15, 0.63); in addition, subjects in the third tertile had a positive and significant association with ACR (ORT3 vs. T1 = 1.96; 95% CI 1.29, 2.97) and increased in eGFR (βT3 vs. T1 = 3.98, 95% CI 0.39, 7.58), compared with subjects in the first tertile.

Conclusions: Our study reports the effect of V on kidney markers in a healthy pediatric population. It could be related to tubulointerstitial lesions and function abnormalities.

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钒暴露和儿科人群的肾脏标志物：一项横断面研究。

背景：人为的钒(V)排放和暴露在一般人群最近有所增加。实验研究表明，V是一种肾毒性物质，但对其对人体肾脏健康的影响知之甚少。本研究评估了在没有任何疾病诊断的儿童人群中尿V浓度与早期肾损伤生物标志物和功能之间的关系。方法：对914名健康受试者进行横断研究，测定尿V浓度、肾小球滤过率（eGFR）、白蛋白-肌酐比（ACR）、尿中肾损伤分子1 （KIM-1）和中性粒细胞明胶酶相关脂钙素（NGAL）的存在。我们使用混杂因素调整的线性和逻辑回归模型来评估V效应。结果：在V的第二和第三十分位数中发现的受试者尿log-NGAL水平升高(βT2 vs. T1 = 0.39；95% CI 0.14, 0.64, βT3 vs. T1 = 1.04；95% CI 0.75, 1.34)和log-KIM-1(βT2 vs. T1 = 0.25；95% CI 0.04, 0.45, βT3 vs. T1 = 0.39；95% ci 0.15, 0.63)；此外，第三分位受试者与ACR呈显著正相关(ORT3 vs. T1 = 1.96；95% CI 1.29, 2.97)和eGFR升高（βT3 vs. T1 = 3.98, 95% CI 0.39, 7.58），与第一分位受试者相比。结论：我们的研究报告了V对健康儿童肾脏标志物的影响。它可能与小管间质病变和功能异常有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Nephrology 医学-泌尿学与肾脏学

CiteScore

4.70

自引率

20.00%

发文量

465

审稿时长

1 months

期刊介绍： International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.