Ofatumumab-associated colitis: A case report.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2025-02-01 Epub Date: 2024-12-07 DOI:10.1177/13524585241303479

Ashish D Patel, Alexa Connors, Megan E Esch

引用次数: 0

Abstract

Background: Colitis has been reported with some anti-CD20 therapies in multiple sclerosis (MS), but not previously with ofatumumab.

Objectives: To report the first case of ofatumumab-associated colitis in MS and discuss its implications.

Methods: Case report.

Results: A 56-year-old female with relapsing-remitting multiple sclerosis (RRMS) developed severe colitis 3 months after initiating ofatumumab, requiring hospitalization and treatment discontinuation.

Conclusion: This case suggests a potential class effect of anti-CD20 therapies, including ofatumumab, in relation to colitis in MS. Clinicians should monitor for gastrointestinal symptoms in MS patients receiving any anti-CD20 therapy.

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ofatumumab相关性结肠炎1例报告

背景：一些抗cd20治疗在多发性硬化症（MS）中有结肠炎的报道，但以前没有使用ofatumumab。目的：报告第一例多发性硬化症的阿图单抗相关性结肠炎，并讨论其意义。方法：病例报告。结果：一名56岁女性复发-缓解型多发性硬化症（RRMS）患者在开始使用阿图单抗3个月后出现严重结肠炎，需要住院并停止治疗。结论：该病例提示抗cd20治疗（包括ofatumumab）与MS结肠炎相关的潜在类效应，临床医生应监测接受任何抗cd20治疗的MS患者的胃肠道症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585