J Bomyea, M M Caudle, A L Bartolovich, A N Simmons, A J Jak, S Golshan
{"title":"Randomized controlled trial of computerized working memory training for Veterans with PTSD.","authors":"J Bomyea, M M Caudle, A L Bartolovich, A N Simmons, A J Jak, S Golshan","doi":"10.1016/j.jpsychires.2024.11.072","DOIUrl":null,"url":null,"abstract":"<p><p>Posttraumatic stress disorder (PTSD) is a common psychiatric condition among Veterans that is associated with deficits across a range of neuropsychological domains including working memory. While gold-standard psychosocial treatments are highly effective, there still remains a high rate of individuals who do not engage with or fully benefit from them. Cognitive training targeting specific working memory deficits in PTSD presents an alternative treatment approach that has shown promise for reducing re-experiencing symptoms. The current study evaluated a 16-session working memory training (WMT) program in Veterans with PTSD, focusing on two levels of interference control training. Feasibility, acceptability, and clinical efficacy were assessed. Results indicated that the intervention was generally feasible and acceptable to Veterans and revealed similar effects between groups in the intent to treat analyses; however, the high interference control training group yielded greater re-experiencing symptom reductions than the low interference control training group among individuals who were protocol adherent (Hedges' g = 0.57). There were significant reductions in overall PTSD severity across groups. Results are broadly consistent with theoretical models and prior clinical trials linking working memory task improvement to re-experiencing symptom reductions. These results point to the potential for working memory training to be a viable intervention for PTSD in Veterans, though further research is necessary for validation and exploration of broader clinical outcomes.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"350-357"},"PeriodicalIF":3.7000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of psychiatric research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jpsychires.2024.11.072","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
Abstract
Posttraumatic stress disorder (PTSD) is a common psychiatric condition among Veterans that is associated with deficits across a range of neuropsychological domains including working memory. While gold-standard psychosocial treatments are highly effective, there still remains a high rate of individuals who do not engage with or fully benefit from them. Cognitive training targeting specific working memory deficits in PTSD presents an alternative treatment approach that has shown promise for reducing re-experiencing symptoms. The current study evaluated a 16-session working memory training (WMT) program in Veterans with PTSD, focusing on two levels of interference control training. Feasibility, acceptability, and clinical efficacy were assessed. Results indicated that the intervention was generally feasible and acceptable to Veterans and revealed similar effects between groups in the intent to treat analyses; however, the high interference control training group yielded greater re-experiencing symptom reductions than the low interference control training group among individuals who were protocol adherent (Hedges' g = 0.57). There were significant reductions in overall PTSD severity across groups. Results are broadly consistent with theoretical models and prior clinical trials linking working memory task improvement to re-experiencing symptom reductions. These results point to the potential for working memory training to be a viable intervention for PTSD in Veterans, though further research is necessary for validation and exploration of broader clinical outcomes.
期刊介绍:
Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research:
(1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors;
(2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology;
(3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;