Role of epigenetic regulation in diminished ovarian reserve.

IF 3.2 3区医学 Q2 GENETICS & HEREDITY

Journal of Assisted Reproduction and Genetics Pub Date : 2025-02-01 Epub Date: 2024-12-07 DOI:10.1007/s10815-024-03301-8

Wen Chen, Li Dong, Chaofeng Wei, Haicui Wu

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引用次数: 0

Abstract

Diminished ovarian reserve (DOR) is characterized by a decrease in the number and quality of oocytes, with its incidence increasing annually. Its pathogenesis remains unclear, making it one of the most challenging problems in the field of assisted reproduction. Epigenetic modification, a molecular mechanism affecting genomic activity and expression without altering the DNA sequence, has been widely studied in reproductive medicine and has attracted considerable attention regarding DOR. This review comprehensively examines the various epigenetic regulatory changes in ovarian granulosa cells (OGCs) and oocytes during DOR. DNA methylation plays a crucial role in regulating granulosa cell function, hormone production, and oocyte development, maturation, and senescence. Histone modifications are involved in regulating follicular activation, while non-coding RNAs, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), regulate granulosa cell function and oocyte development. N6-methyladenosine (m6A) modifications are associated with age-related oocyte senescence. Epigenetic clocks based on DNA methylation show potential in predicting ovarian reserve in DOR. Furthermore, it discusses the potential for utilizing epigenetic mechanisms to better diagnose and manage DOR.

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表观遗传调控在卵巢储备减少中的作用。

卵巢储备减少（DOR）的特征是卵母细胞的数量和质量下降，其发病率逐年增加。其发病机制尚不清楚，使其成为辅助生殖领域最具挑战性的问题之一。表观遗传修饰是一种在不改变DNA序列的情况下影响基因组活性和表达的分子机制，在生殖医学中得到了广泛的研究，并引起了生殖医学领域的广泛关注。本文综述了卵巢颗粒细胞（OGCs）和卵母细胞在DOR过程中的各种表观遗传调控变化。DNA甲基化在调节颗粒细胞功能、激素产生和卵母细胞发育、成熟和衰老中起着至关重要的作用。组蛋白修饰参与调节卵泡活化，而非编码rna，如长链非编码rna （lncRNAs）和微rna (miRNAs)，调节颗粒细胞功能和卵母细胞发育。n6 -甲基腺苷（m6A）修饰与年龄相关的卵母细胞衰老有关。基于DNA甲基化的表观遗传时钟显示了预测DOR卵巢储备的潜力。此外，它还讨论了利用表观遗传机制更好地诊断和管理DOR的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.