Who is at risk of long-term subjective memory impairment after electroconvulsive therapy?

IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY
Elsa Tornhamre , Åsa Hammar , Pia Nordanskog , Axel Nordenskjöld
{"title":"Who is at risk of long-term subjective memory impairment after electroconvulsive therapy?","authors":"Elsa Tornhamre ,&nbsp;Åsa Hammar ,&nbsp;Pia Nordanskog ,&nbsp;Axel Nordenskjöld","doi":"10.1016/j.jad.2024.12.028","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Electroconvulsive therapy (ECT) is an effective treatment for depression with potential transient cognitive side effects. However, subjective memory impairment can extend over a long period after ECT.</div></div><div><h3>Objectives</h3><div>This study aimed to assess potential risk factors for long-term subjective memory impairment 6 months after ECT and to explore if the associations are mediated by depressive symptoms.</div></div><div><h3>Methods</h3><div>This registry-based study used the Swedish National Quality Register for ECT and other national registers. Long-term subjective memory worsening was defined as a minimum 2-step worsening on the memory item from the comprehensive psychopathological rating scale (CPRS-M) from before ECT to 6 months after ECT. Changes on the scale were also analyzed in continuous models. Statistical methods used were logistic regression and linear regression analyses in univariable and multivariable models.</div></div><div><h3>Results</h3><div>The study population consisted of 1498 patients. Subjective memory worsening occurred in 25.2 % of the population. Long-term subjective memory worsening was associated with more depressive symptoms and lower education levels. No association could be found related to ECT technical factors. The associations between age and psychiatric comorbidities with subjective memory worsening were mediated by depressive symptoms.</div></div><div><h3>Conclusion</h3><div>Patients can be informed that depressive symptoms are one of the biggest contributing factors to long-term subjective memory impairment after ECT. A successful treatment is therefore important to minimize the long-term experience of memory deficits. The number of sessions or ECT technical factors do not seem to be associated with long-term subjective memory impairment.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"372 ","pages":"Pages 324-332"},"PeriodicalIF":4.9000,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S016503272402007X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Electroconvulsive therapy (ECT) is an effective treatment for depression with potential transient cognitive side effects. However, subjective memory impairment can extend over a long period after ECT.

Objectives

This study aimed to assess potential risk factors for long-term subjective memory impairment 6 months after ECT and to explore if the associations are mediated by depressive symptoms.

Methods

This registry-based study used the Swedish National Quality Register for ECT and other national registers. Long-term subjective memory worsening was defined as a minimum 2-step worsening on the memory item from the comprehensive psychopathological rating scale (CPRS-M) from before ECT to 6 months after ECT. Changes on the scale were also analyzed in continuous models. Statistical methods used were logistic regression and linear regression analyses in univariable and multivariable models.

Results

The study population consisted of 1498 patients. Subjective memory worsening occurred in 25.2 % of the population. Long-term subjective memory worsening was associated with more depressive symptoms and lower education levels. No association could be found related to ECT technical factors. The associations between age and psychiatric comorbidities with subjective memory worsening were mediated by depressive symptoms.

Conclusion

Patients can be informed that depressive symptoms are one of the biggest contributing factors to long-term subjective memory impairment after ECT. A successful treatment is therefore important to minimize the long-term experience of memory deficits. The number of sessions or ECT technical factors do not seem to be associated with long-term subjective memory impairment.
谁在电休克治疗后有长期主观记忆障碍的危险?
背景:电痉挛疗法(ECT)是一种有效的治疗抑郁症的方法,但有潜在的短暂性认知副作用。然而,电痉挛疗法后,主观记忆障碍会持续很长一段时间。目的:本研究旨在评估ECT后6 个月长期主观记忆障碍的潜在危险因素,并探讨其相关性是否由抑郁症状介导。方法:这项基于注册表的研究使用了瑞典国家质量注册表和其他国家注册表。长期主观记忆恶化定义为从ECT前到ECT后6个 月,综合精神病理评定量表(CPRS-M)中记忆项目至少2级恶化。在连续模型中还分析了尺度的变化。统计方法采用单变量和多变量模型的逻辑回归和线性回归分析。结果:研究人群包括1498例患者。主观记忆恶化发生率为25.2% %。长期主观记忆恶化与更多的抑郁症状和较低的教育水平有关。未发现与电痉挛相关的技术因素。年龄和精神合并症与主观记忆恶化之间的关联是由抑郁症状介导的。结论:患者可以了解到,抑郁症状是ECT术后长期主观记忆障碍的最大因素之一。因此,成功的治疗对于减少记忆缺陷的长期经历非常重要。治疗次数或ECT技术因素似乎与长期主观记忆障碍无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of affective disorders
Journal of affective disorders 医学-精神病学
CiteScore
10.90
自引率
6.10%
发文量
1319
审稿时长
9.3 weeks
期刊介绍: The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信