Intrinsic functional brain connectivity in adolescent anxiety: Associations with behavioral phenotypes and cross-syndrome network features.

IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY
Xavier Yan Heng Lim, Lizhu Luo, Junhong Yu
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引用次数: 0

Abstract

Background: Considerable research has mapped the human brain networks implicated in anxiety. Yet, less is known about the intrinsic features of the brain implicated in adolescent anxiety and their generalizability to affective and behavioral problems. To this end, we investigated the intrinsic functional connectomes associated with anxiety, their associations with behavioral phenotypes of clinical interest, and the cross-syndrome overlap between the anxiety network and other affective syndromes in an adolescent sample.

Methods: We used the Boston Adolescent Neuroimaging of Depression and Anxiety (BANDA) dataset which comprises 203 clinical and healthy adolescents aged 14-17. Participants underwent a resting-state magnetic resonance imaging scan and completed the Child Behavior Checklist (CBCL) and Behavioral Inhibition/Activation System scale. Using network-based statistics, we identified functional networks associated with anxiety and other behavioral syndromes. The anxiety network strengths were then correlated with behavioral measures.

Results: A significant resting-state functional network associated with anxiety was identified, largely characterized by hyperconnectivity between the somatomotor and both the default mode network and subcortical regions. Network strengths derived from the anxiety network were significantly correlated to various behavioral syndromes, including internalizing and externalizing tendencies. Cross-syndrome overlapping edges were also observed in networks of internalizing disorders, more prominently post-traumatic stress syndromes.

Conclusions: Our results revealed the functional connectomes characteristic of anxiety in adolescents. This resting-state functional network was also predictive of and shared similar features with behavioral syndromes typically associated with anxiety-related disorders, providing evidence that the high comorbidity of anxiety with other clinical conditions may have a neurobiological basis.

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来源期刊
Journal of affective disorders
Journal of affective disorders 医学-精神病学
CiteScore
10.90
自引率
6.10%
发文量
1319
审稿时长
9.3 weeks
期刊介绍: The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.
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