Is Lactococcus lactis a Suitable Candidate for Use as a Vaccine Delivery System Against Helicobacter pylori?

IF 2.3 3区 生物学 Q3 MICROBIOLOGY
Faria Hasanzadeh Haghighi, Hadi Farsiani
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Abstract

Helicobacter pylori was described in 1979. This bacterium, which thrives in the harsh conditions of the stomach, is typically acquired during childhood and can remain colonized for life. Approximately, 90% of the global population is affected, and H. pylori is linked to various conditions, including gastritis, peptic ulcers, lymphoproliferative gastric lymphoma, and even gastric cancer. Currently, antibiotics are the primary treatment method, but the associated challenges of antibiotic use have led to the consideration of oral vaccination as a viable preventive measure against this infection. However, the stomach's harsh environment characterized by its acidic conditions and numerous proteolytic enzymes poses significant obstacles to the development and effectiveness of oral vaccines. To address these challenges, researchers have proposed and evaluated several delivery systems. One of the most promising options is the use of probiotics. Among the various probiotics, Lactococcus lactis stands out as a suitable candidate for oral vaccine delivery against H. pylori due to the advancements in genetic engineering that have been applied to it. This review article discusses the limitations of current treatment strategies and rationalizes the shift toward vaccination, particularly oral vaccination for this infection. It also explores the advantages and challenges of using probiotic bacteria, with a focus on L. lactis as a delivery system. Ultimately, despite the existing challenges, L. lactis continues to be recognized as a promising delivery system. Nonetheless, further research is essential to fully assess its effectiveness and address the challenges associated with this approach.

乳酸乳球菌是否适合作为幽门螺杆菌的疫苗递送系统?
幽门螺杆菌于1979年被发现。这种细菌在胃部的恶劣条件下繁殖,通常是在儿童时期获得的,并且可以在一生中保持定植。大约90%的全球人口受到幽门螺杆菌的影响,幽门螺杆菌与各种疾病有关,包括胃炎、消化性溃疡、淋巴增生性胃淋巴瘤,甚至胃癌。目前,抗生素是主要的治疗方法,但抗生素使用的相关挑战已导致考虑口服疫苗接种作为预防这种感染的可行措施。然而,胃的恶劣环境以其酸性条件和大量的蛋白水解酶为特征,这对口服疫苗的开发和有效性构成了重大障碍。为了应对这些挑战,研究人员提出并评估了几种输送系统。最有希望的选择之一是使用益生菌。在各种益生菌中,乳酸乳球菌因其基因工程的进步而成为口服幽门螺杆菌疫苗的合适人选。这篇综述文章讨论了当前治疗策略的局限性,并合理化转向疫苗接种,特别是口服疫苗接种这种感染。它还探讨了使用益生菌的优势和挑战,重点是乳杆菌作为一种输送系统。最终,尽管存在挑战,乳酸菌仍然被认为是一种有前途的输送系统。然而,为了充分评估其有效性并解决与此方法相关的挑战,进一步的研究是必不可少的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Microbiology
Current Microbiology 生物-微生物学
CiteScore
4.80
自引率
3.80%
发文量
380
审稿时长
2.5 months
期刊介绍: Current Microbiology is a well-established journal that publishes articles in all aspects of microbial cells and the interactions between the microorganisms, their hosts and the environment. Current Microbiology publishes original research articles, short communications, reviews and letters to the editor, spanning the following areas: physiology, biochemistry, genetics, genomics, biotechnology, ecology, evolution, morphology, taxonomy, diagnostic methods, medical and clinical microbiology and immunology as applied to microorganisms.
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