GDF-15 as a proxy for epigenetic aging: associations with biological age markers, and physical function.

IF 4.4 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2024-12-07 DOI:10.1007/s10522-024-10165-z

Margalida Torrens-Mas, Cayetano Navas-Enamorado, Aina Galmes-Panades, Luis Masmiquel, Andrés Sanchez-Polo, Xavier Capo, Marta Gonzalez-Freire

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引用次数: 0

Abstract

Growth differentiation factor 15 (GDF-15) has emerged as a significant biomarker of aging, linked to various physiological and pathological processes. This study investigates circulating GDF-15 levels in a cohort of healthy individuals from the Balearic Islands, exploring its associations with biological age markers, including multiple DNA methylation (DNAm) clocks, physical performance, and other age-related biomarkers. Seventy-two participants were assessed for general health, body composition, and physical function, with GDF-15 levels quantified using ELISA. Our results indicate that GDF-15 levels significantly increase with age, particularly in individuals over 60. Strong positive correlations were observed between GDF-15 levels and DNAm GrimAge, DNAm PhenoAge, Hannum, and Zhang clocks, suggesting that GDF-15 could serve as a proxy for epigenetic aging. Additionally, GDF-15 levels were linked to markers of impaired glycemic control, systemic inflammation, and physical decline, including decreased lung function and grip strength, especially in men. These findings highlight the use of GDF-15 as a biomarker for aging and age-related functional decline. Given that GDF-15 is easier to measure than DNA methylation, it has the potential to be more readily implemented in clinical settings for broader health assessment and management.

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GDF-15作为表观遗传衰老的代理：与生物年龄标志物和身体功能的关联

生长分化因子15 （GDF-15）已成为衰老的重要生物标志物，与各种生理和病理过程有关。本研究调查了一组来自巴利阿里群岛的健康个体的循环GDF-15水平，探索其与生物年龄标志物的关系，包括多个DNA甲基化（DNAm）时钟、身体表现和其他与年龄相关的生物标志物。对72名参与者进行了总体健康、身体组成和身体功能评估，并使用ELISA对GDF-15水平进行了量化。我们的研究结果表明，GDF-15水平随着年龄的增长而显著增加，特别是在60岁以上的个体中。GDF-15水平与DNAm GrimAge、DNAm PhenoAge、Hannum和Zhang时钟之间存在强烈的正相关，表明GDF-15可以作为表观遗传衰老的代理。此外，GDF-15水平与血糖控制受损、全身炎症和身体衰退有关，包括肺功能和握力下降，尤其是在男性中。这些发现强调了GDF-15作为衰老和年龄相关功能衰退的生物标志物的应用。鉴于GDF-15比DNA甲基化更容易测量，它有可能更容易在临床环境中实施，用于更广泛的健康评估和管理。

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.