Exploring the cognitive effects of kratom: A review.

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2025-03-05 Epub Date: 2024-12-05 DOI:10.1016/j.bbr.2024.115387

Farah Wahida Suhaimi, Nurul Husna Mohamad Khari, Zurina Hassan, Christian P Müller

{"title":"Exploring the cognitive effects of kratom: A review.","authors":"Farah Wahida Suhaimi, Nurul Husna Mohamad Khari, Zurina Hassan, Christian P Müller","doi":"10.1016/j.bbr.2024.115387","DOIUrl":null,"url":null,"abstract":"<p><p>Despite the strict kratom regulation in some regions, the demand for kratom products is still increasing worldwide. Kratom products are commonly consumed for their pain-relieving effect or as a self-treatment for opioid use disorder. Kratom is also taken as a recreational drug among youth and adults. Since substance abuse can cause cognitive impairment, many studies investigated the effects of kratom on cognition. The interaction of some kratom alkaloids with various receptors such as opioid, serotonergic, and adrenergic receptors further sparks the interest to investigate the effects of kratom on cognitive function. Hence, this review aims to provide an overview of the effects of kratom on cognitive behaviours and their underlying changes in neurobiological mechanisms. In conclusion, kratom, particularly its main alkaloid, mitragynine may adversely affect cognitive performances that may be attributed to the disruption in synaptic plasticity, brain activity as well as various proteins involved in synaptic transmission. The impact of kratom on cognitive functions could also shed light on its safety profile, which is essential for the therapeutic development of kratom, including its potential use in opioid substitution therapy.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115387"},"PeriodicalIF":2.6000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Behavioural Brain Research","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1016/j.bbr.2024.115387","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/5 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Despite the strict kratom regulation in some regions, the demand for kratom products is still increasing worldwide. Kratom products are commonly consumed for their pain-relieving effect or as a self-treatment for opioid use disorder. Kratom is also taken as a recreational drug among youth and adults. Since substance abuse can cause cognitive impairment, many studies investigated the effects of kratom on cognition. The interaction of some kratom alkaloids with various receptors such as opioid, serotonergic, and adrenergic receptors further sparks the interest to investigate the effects of kratom on cognitive function. Hence, this review aims to provide an overview of the effects of kratom on cognitive behaviours and their underlying changes in neurobiological mechanisms. In conclusion, kratom, particularly its main alkaloid, mitragynine may adversely affect cognitive performances that may be attributed to the disruption in synaptic plasticity, brain activity as well as various proteins involved in synaptic transmission. The impact of kratom on cognitive functions could also shed light on its safety profile, which is essential for the therapeutic development of kratom, including its potential use in opioid substitution therapy.

查看原文本刊更多论文

Kratom的认知效应研究综述。

尽管在一些地区有严格的kratom法规，但全球对kratom产品的需求仍在增加。Kratom产品通常因其缓解疼痛的效果或作为阿片类药物使用障碍的自我治疗而被消费。克拉托姆也被青少年和成年人当作消遣性毒品服用。由于药物滥用会导致认知障碍，许多研究调查了kratom对认知的影响。一些苦参生物碱与阿片受体、血清素受体和肾上腺素受体的相互作用进一步激发了研究苦参对认知功能影响的兴趣。因此，本综述旨在概述kratom对认知行为的影响及其在神经生物学机制中的潜在变化。综上所述，苦参，尤其是其主要生物碱米特拉金碱可能会对认知表现产生不利影响，这可能归因于突触可塑性、大脑活动以及参与突触传递的各种蛋白质的破坏。kratom对认知功能的影响也可以揭示其安全性，这对于kratom的治疗发展至关重要，包括其在阿片类药物替代治疗中的潜在用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.